Hazard assessment of hexagonal boron nitride and hexagonal boron nitride reinforced thermoplastic polyurethane composites using human skin and lung cells
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Le résumé fourni par la source
Hexagonal boron nitride (hBN) is an emerging two-dimensional material attracting considerable attention in the industrial sector given its innovative physicochemical properties. Potential risks are associated mainly with occupational exposure where inhalation and skin contact are the most relevant exposure routes for workers. Here we aimed at characterizing the effects induced by composites of thermoplastic polyurethane (TPU) and hBN, using immortalized HaCaT skin keratinocytes and BEAS-2B bronchial epithelial cells. The composite was abraded using a Taber® rotary abraser and abraded TPU and TPU-hBN were also subjected to photo-Fenton-mediated degradation mimicking potential weathering across the product life cycle. Cells were exposed to the materials for 24 h (acute exposure) or twice per week for 4 weeks (chronic exposure) and evaluated with respect to material internalization, cytotoxicity, and proinflammatory cytokine secretion. Additionally, comprehensive mass spectrometry-based proteomics and metabolomics (secretomics) analyses were performed. Overall, despite evidence of cellular uptake of the material, no significant cellular and/or protein expression profiles alterations were observed after acute or chronic exposure of HaCaT or BEAS-2B cells, identifying only few pro-inflammatory proteins. Similar results were obtained for the degraded materials. These results support the determination of hazard profiles associated with cutaneous and pulmonary hBN-reinforced polymer composites exposure. Beside graphene, only limited information is available about other 2D materials, such as hexagonal boron nitride (hBN). Beside the paucity of toxicological data on hBN, the hazard potential of hBN-containing products is seldom evaluated. Nevertheless, the risk for the environment, as well as for human health, could be associated not only with pristine material properties, but also with particles released after mechanical degradation during hBN-reinforced products life cycle. This study provides information on what is qualitatively and quantitatively released from an industrially-relevant hBN-reinforced composite, with careful hazard characterization from a life cycle perspective using immortalized human skin and lung cells.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Hazard assessment of hexagonal boron nitride and hexagonal boron nitride reinforced thermoplastic polyurethane composites using human skin and lung cells
- Date Crossref
- 01/07/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Trieste Department of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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Karolinska Institutet pays non établi dans la noticeUniversité ou école supérieure
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Italian Institute of Technology Analytical Chemistry Facility pays non établi dans la noticeStructure de recherche
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Centre National de la Recherche Scientifique pays non établi dans la noticeOrganisme public
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Institut de Science et d'Ingénierie Supramoléculaires pays non établi dans la noticeStructure de recherche
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Immunologie pays non établi dans la noticeStructure de recherche
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Institut de Biologie Moléculaire et Cellulaire I2CT - Immunologie pays non établi dans la noticeStructure de recherche
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Université de Strasbourg pays non établi dans la noticeUniversité ou école supérieure
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SIB Swiss Institute of Bioinformatics pays non établi dans la noticeOrganisation à but non lucratif
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Board of the Swiss Federal Institutes of Technology pays non établi dans la noticeOrganisme public
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ETH Zurich pays non établi dans la noticeUniversité ou école supérieure
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Swiss Federal Laboratories for Materials Science and Technology pays non établi dans la noticeStructure de recherche
Department of Life Sciences — University of Trieste, Karolinska Institutet et Analytical Chemistry Facility — Italian Institute of Technology, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.