Accès ouvert
2024
article
OpenAlex
Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba et autres
A newly designed and synthesized low-molecular-weight fucoidan analogue was found to inhibit not only heparanase activity but also infection by the SARS-CoV-2 Wuhan strain and two Omicron subvariants, BA.2 and BA.5, as reported by Kazunobu Toshima, Daisuke Takahashi, and co-workers in their …
jp
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba et autres
A newly designed and synthesized low-molecular-weight fucoidan analogue was found to inhibit not only heparanase activity but also infection by the SARS-CoV-2 Wuhan strain and two Omicron subvariants, BA.2 and BA.5, as reported by Kazunobu Toshima, Daisuke Takahashi, and co-workers in their …
jp
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba et autres
Abstract Heparan sulfate (HS) is ubiquitous on cell surfaces and is used as a receptor by many viruses including SARS‐CoV‐2. However, increased activity of the inflammatory enzyme heparanase (HPSE), which hydrolyses HS, in patients with COVID‐19 not only increases the severity of …
jp
(code pays fourni par la source)