Shunya Tsuji

Sequential administration of sclerostin antibody and parathyroid hormone differentially modulates fracture healing in a murine tibial osteotomy model

Atsushi Mihara, Kiminori Yukata, Norihiro Nishida, Tetsuya Seto et autres

Anabolic agents such as parathyroid hormone (PTH) analogs and sclerostin antibody (Scl-Ab) enhance fracture healing through distinct mechanisms, but whether the order of administration affects healing remains unclear. In a murine tibial osteotomy model, we compared PTH monotherapy (40 μg/kg), Scl-Ab monotherapy …

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Renoprotective effects of gut NHE3 inhibitor tenapanor in a rat model of unilateral renal ischemia–reperfusion injury with contralateral nephrectomy

Mitsuhiro Yamaguchi, Yukihiro Hitaka, Shunya Tsuji, Masashi Ogawa et autres

Kidney ischemia-reperfusion (I/R) injury is an unavoidable complication of kidney transplantation that contributes to acute kidney injury (AKI), chronic kidney disease (CKD), and limited long-term graft survival. Elevated serum phosphate has been implicated not only as a consequence of renal dysfunction but …

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Senescence-like cells recruit γδ T cells to drive prolonged hyposmia after SARS-CoV-2 infection in mice

Shunya Tsuji, Sosuke Nakano, Koyu Ito, Shohei Minami et autres

Persistent hyposmia is a hallmark of post COVID-19 conditions, yet the mechanisms sustaining olfactory dysfunction after viral clearance remain poorly understood. Here, using mouse models of SARS-CoV-2 infection, we show that virus-induced senescence-like changes in uninfected olfactory mucosal fibroblasts persist long after …

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p16High immune cells control disease tolerance as a defense and health span-extending strategy

Francisco Triana-Martínez, Alessandra Pierantoni, Daisy Graça, Veronica Bergo et autres

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Switching of the c-Myc protein degradation pathway depending on the PP2A-B55α complex levels

Sana Ando, Shunta Ikeda, Keiko Tanaka, Yuri Tomabechi et autres

The transcription factor c-Myc is a master oncoprotein that regulates over 15% of all genes. Protein phosphatase 2A (PP2A), a crucial tumor suppressor, destabilizes c-Myc protein. Classically, PP2A-mediated dephosphorylation of Ser62 followed by Thr58 phosphorylation was thought to promote ubiquitination of c-Myc …

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Necrotic-cell–activated macrophages drive an ERK–Bcl-xL survival pathway in osteoclasts and confer bisphosphonate resistance

Kazuya Uehara, Keiichi Katō, Shunya Tsuji, Kiminori Yukata et autres

Nontraumatic osteonecrosis of the femoral head (ONFH) is a progressive disorder marked by ischemic necrosis of subchondral bone, often leading to femoral head collapse. Although bisphosphonates effectively target osteoclasts in osteoporosis and show benefit in ONFH animal models, their effectiveness to prevent …

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Inflammatory biomarkers predict Cutibacterium acnes detection at the portal area during arthroscopic shoulder surgery

Kazuya Uehara, Kiminori Yukata, Takashi Imagama, Shunya Tsuji et autres

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Denosumab associated with accelerated progression of abdominal aortic calcification among patients on dialysis

Tetsuya Seto, Kiminori Yukata, Zenzo Fujii, Masaaki Shibuya et autres

Chronic kidney disease (CKD) is associated with disturbances in bone and mineral metabolism, leading to osteoporosis and vascular calcification, which are significant contributors to mortality. Although denosumab, a monoclonal antibody targeting RANKL, has been shown to increase BMD, its effects on vascular …

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Two Distinct Mechanisms of PP2A Regulation by Methylesterase PME ‐1 Are Both Essential for Mouse Development

Shunta Ikeda, Sana Ando, Nana Kishida, Keiko Tanaka et autres

Protein methylesterase-1 (PME-1) is an essential enzyme that catalyzes the demethylation of protein phosphatases 2A (PP2A) and PP4 catalytic subunits to alter the composition of holoenzymes. Elevated PME-1 protein levels are observed in neurodegenerative diseases and cancer, suggesting the involvement of dysregulation …

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Two Distinct Mechanisms of PP2A Regulation by Methylesterase PME-1 Are Both Essential for Mouse Development

Shunta Ikeda, Sana Ando, Nana Kishida, Keiko Tanaka et autres

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Cell cycle checkpoint factor p15Ink4b is a novel regulator of osteoclast differentiation

Shunya Tsuji, Akihiko Sakamoto, Kenji Takemoto, Tetsuya Seto et autres

Osteoclasts are specialized cells essential for bone resorption, a crucial process in bone remodeling, and dysregulation of osteoclastogenesis can lead to pathological bone loss such as osteoporosis and rheumatoid arthritis. Therefore, understanding the precise mechanisms governing osteoclast differentiation is crucial for developing …

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Dietary intake of whale oil–containing ω‐3 long‐chain polyunsaturated fatty acids attenuates choroidal neovascularization in mice

Ryoji Yanai, Genta Yasunaga, Shunya Tsuji, Takeshi Honda et autres

Age-related macular degeneration (AMD) is a leading cause of blindness in Western and developing countries. Since antivascular endothelial growth factor (VEGF) therapy is available for the regression of choroidal neovascularization (CNV), it does not work for the pathophysiology of AMD so a …

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