Takeharu Minamitani

PDGFRα governs multiple cellular signals and plays a protective role in tumor progression

Masao Hayashi, Noriko Okuno, Liem Q. Trang, Ayaka Inami et autres

Extensive research has been done on the molecular mechanisms of tumor development and growth. However, multiple aspects remain elusive. We examined cellular signaling mechanisms involving platelet-derived growth factor (PDGF) and its receptor (PDGFR), using adult PDGFRα conditional knockout (α-KO) mice implanted with …

jp, vn (code pays fourni par la source)

Development of a recombinant hepatitis B immunoglobulin derived from B cells collected from healthy individuals administered with hepatitis B virus vaccines: A feasibility study

Rika A. Furuta, Teruhito Yasui, Takeharu Minamitani, Hiroki Akiba et autres

Abstract Background In Japan, plasma with a high concentration of Hepatitis B Virus (HBV) antibodies for hepatitis B immunoglobulin (HBIG) is almost entirely imported. We aimed to produce recombinant HBIG by isolating immunoglobulin cDNAs against the HBV surface antigen (HBsAg). Study Design …

jp (code pays fourni par la source)

Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein

Ryota Otsubo, Takeharu Minamitani, Kouji Kobiyama, Junso Fujita et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Variants of concern (VOCs) such as Delta and Omicron have developed, which continue to spread the pandemic. It has been reported that these VOCs reduce vaccine efficacy and evade many …

jp (code pays fourni par la source)

Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support

Toshihiro Ito, Takeharu Minamitani, Masaki Hayakawa, Ryota Otsubo et autres

ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type-1 motif 13)-related bleeding disorder has been frequently observed as a life-threatening clinical complication in patients carrying a circulatory assist device. Currently, treatment modalities for the bleeding disorder are very limited and not always successful. …

jp (code pays fourni par la source)

Optimization of Anti-ADAMTS13 Antibodies for the Treatment of ADAMTS13-Related Bleeding Disorder in Patients Receiving Circulatory Assist Device Support

Toshihiro Ito, Takeharu Minamitani, Masaki Hayakawa, Ryota Otsubo et autres

Abstract ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type-1 motif 13)-related bleeding disorder has been frequently observed as a life-threatening clinical complication in patients carrying a circulatory assist device. Currently, treatment modalities for the bleeding disorder are very limited and not always …

jp (code pays fourni par la source)

Novel neutralizing human monoclonal antibodies against tetanus neurotoxin

Takeharu Minamitani, Karin Kiyose, Ryota Otsubo, Toshihiro Ito et autres

Tetanus is a fatal disease caused by tetanus neurotoxin (TeNT). TeNT is composed of a light chain (Lc) and a heavy chain, the latter of which is classified into two domains, N-terminus Hn and C-terminus Hc. Several TeNT-neutralizing antibodies have been reported, …

jp (code pays fourni par la source)

Novel neutralizing human monoclonal antibodies against tetanus neurotoxin

Takeharu Minamitani, Karin Kiyose, Ryota Otsubo, Toshihiro Ito et autres

Abstract Tetanus is a fatal disease caused by tetanus neurotoxin (TeNT). TeNT is composed of a light chain (Lc) and a heavy chain, the latter of which is classified into two domains, N-terminus Hn and C-terminus Hc. Several TeNT-neutralizing antibodies have been …

jp, nz (code pays fourni par la source)

Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway

Mizuki Watanabe, Jun Arii, Kosuke Takeshima, Ayano Fukui et autres

Herpesviruses are ubiquitous pathogens of various animals, including humans. These viruses primarily pass through cell junctions to spread to uninfected cells. This method of cell-to-cell spread is an important pathogenic characteristic of these viruses. Here, we show that the host cell protein …

jp (code pays fourni par la source)

The Kg‐antigen, RhAG with a Lys164Gln mutation, gives rise to haemolytic disease of the newborn

Mitsunobu Tanaka, Takaaki Abe, Takeharu Minamitani, Hiroki Akiba et autres

The Kg-antigen was first discovered in an investigation of a mother whose infant had haemolytic disease of the newborn (HDN). The antibody against the Kg-antigen is believed to be responsible for HDN. The Kg-antigen is provisionally registered under the number 700045, according …

jp (code pays fourni par la source)

Comprehensive analysis for humoral immune responses to Cytomegalovirus infection

Takeharu Minamitani

Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection

Shuhei Sakakibara, Teruhito Yasui, Hideyuki Jinzai, Kristy O’Donnell et autres

Immune responses against certain viruses are accompanied by auto-antibody production although the origin of these infection-associated auto-antibodies is unclear. Here, we report that murine γ-herpesvirus 68 (MHV68)-induced auto-antibodies are derived from polyreactive B cells in the germinal center (GC) through the activity …

jp, au (code pays fourni par la source)

Bystander inhibition of humoral immune responses by Epstein–Barr virus LMP1

Chao‐Yuan Tsai, Shuhei Sakakibara, Teruhito Yasui, Takeharu Minamitani et autres

Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1), which mimics a constitutively active receptor, is required for viral transformation of primary B cells. LMP1 is expressed in EBV-infected germinal center (GC) B cells of immunocompetent individuals, suggesting that it may contribute to …

jp (code pays fourni par la source)