Miriam Stenzinger

Impaired hematopoiesis affects apheresis and CAR T‐cell product composition and treatment response

Hanna Kuhn, Felix Korell, Angela Hückelhoven‐Krauss, Brigitte Neuber et autres

Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of hematologic malignancies, but its success depends on obtaining sufficient CD3 + T‐cell yields during leukapheresis. This can be difficult in heavily pretreated patients, who often show leukopenia and reduced …

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Contribution of genetics to hematopoietic stem cell mobilization: a genomewide association study of 564 healthy donors mobilized with granulocyte colony-stimulating factor

Miriam Stenzinger, Susanne Beck, Iordanis Ourailidis, Anna‐Lena Volckmar et autres

Hematopoietic stem and progenitor cells (HSPC) from mobilized blood are the preferred graft source for allogeneic and autologous stem cell transplantation. The efficiency of CD34+ cell mobilization with granulocyte colony-stimulating factor (G-CSF) varies significantly between individuals, but is reproducible across mobilization cycles …

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Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen

Yu‐Chan Chih, Amelie Christina Dietsch, Philipp Koopmann, Xiujian Ma et autres

Abstract T cell receptor-engineered T cells (TCR-T) could be advantageous in glioblastoma by allowing safe and ubiquitous targeting of the glioblastoma-derived peptidome. Protein tyrosine phosphatase receptor type Z1 (PTPRZ1), is a clinically targetable glioblastoma antigen associated with glioblastoma cell stemness. Here, we …

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Transgenic T cell therapy targeting the glioblastoma stem cell antigen PTPRZ1 with a vaccine-induced, patient-derived T cell receptor

Lukas Bunse, Yu‐Chan Chih, Amelie Christina Dietsch, Philipp Koopmann et autres

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Treatment of chronic COVID ‐19 with convalescent/postvaccination plasma in patients with hematologic malignancies

Maike Janssen, Albrecht Leo, Cornelia E. Wolf, Miriam Stenzinger et autres

Immunocompromised patients are at high risk to fail clearance of SARS-CoV-2. Prolonged COVID-19 constitutes a health risk and a management problem as cancer treatments often have to be disrupted. As SARS-CoV-2 evolves, new variants of concern have emerged that evade available monoclonal …

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P06.05.A INTRACEREBROVENTRICULAR TCR-TRANSGENIC T CELL THERAPY TO TREAT GLIOBLASTOMA (INVENT4GB)

Lukas Bunse, Markus Kratzmann, Yun-Ting Chih, Khwab Sanghvi et autres

Abstract BACKGROUND Novel concepts in immunotherapy have evolved with the identification of potential (neo)epitopes and/or combinations with immune checkpoint inhibitors (ICI). In contrast to many other solid tumors, ICI have not improved outcome for patients with glioblastoma (GB) in phase 3 studies. …

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Early Development of Ubiquitous Acanthocytosis and Extravascular Hemolysis in Lung Cancer Patients Receiving Alectinib

J. Kunz, Christiane Wiedemann, Heidrun Grosch, Katharina Kriegsmann et autres

Alectinib is a standard initial treatment for patients with advanced anaplastic lymphoma kinase (ALK) rearranged non-small-cell lung cancer (NSCLC). The current study analyzed a prospective cohort of 24 consecutive alectinib-treated patients and controls in order to comprehensively characterize longitudinal erythrocyte changes under …

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Hematopoietic-Extrinsic Cues Dictate Circadian Redistribution of Mature and Immature Hematopoietic Cells in Blood and Spleen

Miriam Stenzinger, Darja Karpova, Christian Unterrainer, Sabine Harenkamp et autres

Circadian oscillations in circulating leukocyte subsets including immature hematopoietic cells have been appreciated; the origin and nature of these alterations remain elusive. Our analysis of wild-type C57BL/6 mice under constant darkness confirmed circadian fluctuations of circulating leukocytes and clonogenic cells in blood …

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Risks of leukapheresis and how to manage them—A non-systematic review

Miriam Stenzinger, Halvard B. Bonig

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