Yukiko Okazaki

Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes

Takayoshi Sasako, Kohjiro Ueki, Kengo Miyoshi, Kana Miyake et autres

Importance: Prevention of diabetic retinopathy is important to keep vision and quality of life. Objective: To examine the effects of an intensive multifactorial intervention and hypoglycemia on retinopathy in people with type 2 diabetes. Design, Setting, and Participants: J-DOIT3 (Japan Diabetes Optimal …

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Severe and Prolonged Hypoglycemia Following Adrenalectomy for Pheochromocytoma: A Case Report

Masahiko Kawasumi, Yoshiro Sakamoto, Yuka Tosaka, Yukiko Okazaki

We report a case of a 64-year-old woman with poorly controlled diabetes mellitus who was found to have a left adrenal pheochromocytoma. Despite standard preoperative management including alpha-blockade with doxazosin, the patient developed persistent and severe hypoglycemia immediately following adrenalectomy, requiring high-rate …

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Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance

Naoki Kobayashi, Yukiko Okazaki, Aya Iwane, Kazuo Hara et autres

Orchestrated hormonal interactions in response to feeding and fasting play a pivotal role in regulating glucose homeostasis. Here, we show that in obesity, the production of follistatin-like 3 (FSTL3), an endogenous inhibitor of Activin B, in adipose tissue is increased in both …

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Elucidation of the clinical traits of diabetic chorea through a questionnaire survey of people with diabetic chorea from 59 Japanese hospitals

Naoko Arakawa, Tomohisa Aoyama, Hirotsugu Suwanai, Gotaro Toda et autres

AIMS: Diabetic chorea refers to sudden involuntary movements developing in people with diabetes mellitus and is known to occur mainly in those with severe hyperglycemia. We conducted a questionnaire survey of case-reporting facilities in Japan to elucidate their clinical characteristics. METHODS: We …

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Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance

Kohjiro Ueki, Naoki Kobayashi, Yukiko Okazaki, Aya Iwane et autres

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Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice

Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko et autres

Aging is considered to be accelerated by insulin signaling in lower organisms, but it remained unclear whether this could hold true for mammals. Here we show that mice with skeletal muscle-specific double knockout of Akt1/2, key downstream molecules of insulin signaling, serve …

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Effect of a Multifactorial Intervention on Fracture in Patients With Type 2 Diabetes: Subanalysis of the J-DOIT3 Study

Takayoshi Sasako, Kohjiro Ueki, Kana Miyake, Yukiko Okazaki et autres

AIMS: To evaluate the effects of an intensified multifactorial intervention and patient characteristics on the incidence of fractures comorbid with type 2 diabetes. METHODS: Fracture events were identified and analyzed among adverse events reported in the J-DOIT3 study, a multicenter, open-label, randomized, …

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Multifactorial intervention has a significant effect on diabetic kidney disease in patients with type 2 diabetes

Kohjiro Ueki, Takayoshi Sasako, Yukiko Okazaki, Kana Miyake et autres

To evaluate the effect of multifactorial intervention on the onset and progression of diabetic kidney disease in the patients with type 2 diabetes, we analyzed the effects of intensified multifactorial intervention by step-wise intensification of medications and life-style modifications (intensive therapy treatment …

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Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

Gotaro Toda, Kotaro Soeda, Yukiko Okazaki, Naoki Kobayashi et autres

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Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism

Takayoshi Sasako, Mitsuru Ohsugi, Naoto Kubota, Shinsuke Itoh et autres

Dynamic metabolic changes occur in the liver during the transition between fasting and feeding. Here we show that transient ER stress responses in the liver following feeding terminated by Sdf2l1 are essential for normal glucose and lipid homeostasis. Sdf2l1 regulates ERAD through …

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Effect of Multifactorial Intervention on Diabetic Kidney Disease in Patients with Type 2 Diabetes

Kohjiro Ueki, Takayoshi Sasako, Yukiko Okazaki, Kana Miyake et autres

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The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis

Masatoshi Kobayashi, Mitsuru Ohsugi, Takayoshi Sasako, Motoharu Awazawa et autres

Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle modulators, the precise mechanism remains unclear. N6-Methyladenosine (m6A) posttranscriptional RNA modification, whose methylation and …

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