Toshihiro Umehara

defineOptions: Define and Parse Command Line Options

Toshihiro Umehara

Parses command line arguments and supplies values to scripts. Users can specify names to which parsed inputs are assigned, value types into which inputs are cast, long options or short options, input splitters and callbacks that define how options should be specified …

Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice

Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko et autres

Aging is considered to be accelerated by insulin signaling in lower organisms, but it remained unclear whether this could hold true for mammals. Here we show that mice with skeletal muscle-specific double knockout of Akt1/2, key downstream molecules of insulin signaling, serve …

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Row by Row Data Processing Tool, Using 'DataSailr' Script [R package datasailr version 0.8.10]

Toshihiro Umehara

datasailr - An R Package for Row by Row Data Processing, Using DataSailr Script

Toshihiro Umehara

Data processing and data cleaning are essential steps before applying statistical or machine learning procedures (García et al., 2015;Pyle, 1999).R provides a flexible way for data processing using vectors.Additional R packages also provide other ways for manipulating data such as using SQL …

datasailr: Row by Row Data Processing Tool, Using 'DataSailr' Script

Toshihiro Umehara

Crystal structure of MBP fused split FKBP-FRB T2098L mutant in complex with rapamycin

Masaki Kikuchi, Dongling Wu, Tatsuya Inoue, Toshihiro Umehara

Crystal structure of MBP fused split FKBP in complex with rapamycin

Masaki Kikuchi, Dongling Wu, Tatsuya Inoue, Toshihiro Umehara

Tankyrase-2 in complex with RK-582

Hitoshi Niwa, Fumiyuki Shirai, Shogo Sato, Takashi Tsumura et autres

Combination use of liraglutide and insulin to Japanese patients with multiple insulin injection: efficacy and cost

Sellami-Mnif Houda, Toshihiro Umehara, Yuriko Yamazaki, Hiroyuki Otake et autres

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Nonalcoholic fatty liver disease with elevated alanine aminotransferase levels is negatively associated with bone mineral density: Cross-sectional study in U.S. adults

Toshihiro Umehara

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has been reported to have a negative effect on bone mineral density (BMD) in Asian populations. Whether such an association exists in Western populations is less clear. METHODS: This cross-sectional analysis of data from NHANES III, …

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The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis

Masatoshi Kobayashi, Mitsuru Ohsugi, Takayoshi Sasako, Motoharu Awazawa et autres

Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle modulators, the precise mechanism remains unclear. N6-Methyladenosine (m6A) posttranscriptional RNA modification, whose methylation and …

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Tankyrase-2 in complex with compound 1a

Hitoshi Niwa, Fumiyuki Shirai, Shogo Sato, Nobuko Yoshimoto et autres