Wenhua Kuang

Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

Xue Mei Lu, Jiacheng Gui, Hainei Pan, Fan Wu et autres

cn, hk, us (code pays fourni par la source)

Structural basis for RNA synthesis and inhibition of the orthobunyavirus polymerase

Jingjing Tang, Wenhua Kuang, Wei Chen, H B Wu et autres

Orthobunyaviruses are segmented negative-sense RNA viruses that encompass several life-threatening human and animal pathogens. However, no licensed antivirals are currently available. The viral RNA-dependent RNA polymerase (RdRp) is a multi-domain enzyme critical for genome replication and transcription, representing a promising target for …

cn (code pays fourni par la source)

SARS-CoV-2 3CLpro mutations T21I and E166A confer differential resistance to simnotrelvir, bofutrelvir, and ensitrelvir

Lu Chen, Haixia Su, Weijuan Shang, Tianqing Nie et autres

ABSTRACT Inhibiting the catalytic activity of 3CLpro is a mainstream strategy to block coronavirus replication. However, the appearance of SARS-CoV-2 3CLpro resistance to protease inhibitors raises concerns for effective therapies. In this work, we first investigated the resistance profile of simnotrelvir, an …

cn (code pays fourni par la source)

Eupalinolide B Alleviates Oxidative Stress in LPS-Induced RAW264.7 Macrophages via Covalently Binding to PRDX4

Ruishen Zhuge, Jianru Liu, Yueming Tian, Lirun Zhou et autres

Background/Objectives: Eupalinolide B (EB), a natural compound derived from Eupatorium lindleyanum DC, has demonstrated multiple pharmacological activities. However, its role in modulating oxidative stress remains incompletely understood. Methods: In this study, we investigated the antioxidant effect and underlying mechanism of EB in …

us, cn (code pays fourni par la source)

Humanization and engineering of protective antibodies targeting severe fever with thrombocytopenia syndrome virus Gn protein

Xuanxiu Ren, Wei Deng, Feiyang Yu, Wenhua Kuang et autres

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly lethal tick-borne bunyavirus with no approved therapies. We previously developed a murine-human chimeric antibody S2A5, which provides complete protection against lethal SFTSV infection, but its clinical use is limited by potential immunogenicity …

cn (code pays fourni par la source)

Structure and function of the nairovirus cap-snatching endonuclease

Wenhua Kuang, Zhenhua Tian, Gan Zhang, Fan Wu et autres

Nairoviruses include several human pathogens such as Crimean-Congo hemorrhagic fever virus (CCHFV) and Kasokero virus (KASV). The cap-snatching endonuclease (EN) domain of the viral polymerase is essential for transcription and represents a promising antiviral target. However, the structural and functional mechanisms of …

cn (code pays fourni par la source)

Antigenic landscape of Nipah virus attachment glycoprotein analysis reveals a protective immunodominant epitope across species

Dan Zhou, Yong Wang, Yanfeng Yao, Wenhua Kuang et autres

Nipah virus (NiV) and Hendra virus (HeV), two highly pathogenic Henipaviruses (HNVs), pose a significant public health threat. The attachment glycoprotein (G) plays a crucial role in viral attachment and entry, making it an attractive target for vaccine and therapeutic antibody development. …

cn (code pays fourni par la source)

Structural insight into RNA encapsidation by the severe fever with thrombocytopenia syndrome virus nucleocapsid protein

Yong Wang, Hao Wu, Jiawen Sun, Wenhua Kuang et autres

Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging highly pathogenic bunyavirus, poses a significant public health threat with a case fatality rate of up to 30%. The viral nucleocapsid protein (NP) encapsidates the genomic RNA to form a ribonucleoprotein (RNP) complex, …

cn (code pays fourni par la source)

Structure and function of the nairovirus cap-snatching endonuclease

Wenhua Kuang, Gan Zhang, Fan Wu, Jinyue Li et autres

Abstract Nairoviruses include several human pathogens such as Crimean-Congo hemorrhagic fever virus (CCHFV) and Kasokero virus (KASV). The cap-snatching endonuclease (EN) domain of the viral polymerase is essential for transcription and represents a promising antiviral target. However, the structural and functional mechanisms …

cn, cz (code pays fourni par la source)

Design and synthesis of protoberberine analogues to alleviate LPS-induced acute lung injury by targeting HCK and blocking the HCK-NLRP3 axis

Tianyun Fan, Guanjun Li, Huiying Li, Liting Xu et autres

cn (code pays fourni par la source)

Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer

Qixiang Shi, Huiying Li, Peili Wang, Fuchao Chen et autres

cn (code pays fourni par la source)

Neutralizing antibodies elicited by Nipah virus G-head nanoparticle target diverse sites and inhibit receptor binding and fusion

Dan Zhou, Yong Wang, Yanfeng Yao, Wenhua Kuang et autres

Abstract Nipah virus (NiV) and Hendra virus (HeV), two highly pathogenic Henipaviruses (HNVs), pose a significant public health threat. The attachment glycoprotein (G) plays a crucial role in viral attachment and entry, making it an attractive target for vaccine and therapeutic antibody …

cn (code pays fourni par la source)