Weijuan Shang

SARS-CoV-2 3CLpro mutations T21I and E166A confer differential resistance to simnotrelvir, bofutrelvir, and ensitrelvir

Lu Chen, Haixia Su, Weijuan Shang, Tianqing Nie et autres

ABSTRACT Inhibiting the catalytic activity of 3CLpro is a mainstream strategy to block coronavirus replication. However, the appearance of SARS-CoV-2 3CLpro resistance to protease inhibitors raises concerns for effective therapies. In this work, we first investigated the resistance profile of simnotrelvir, an …

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Discovery and mechanistic insights of dibenzoylmethane as a broad spectrum inhibitor of coronavirus

Yuan Sun, Xiaoyang Shu, Lu Chen, Weijuan Shang et autres

Coronavirus, a large family of positive-sense RNA viruses, are responsible for both mild and severe respiratory illnesses, ranging from the common cold to life-threatening conditions. Despite significant advances in vaccine and antiviral development, the high mutability of human coronaviruses (HCoVs), such as …

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Substrate recognition and cleavage mechanism of the monkeypox virus core protease

Yan Gao, Xiong Xie, Xiaoyu Zhang, Junyuan Cao et autres

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Targeting viral suppressor of RNAi confers anti-coronaviral activity

Jiyao Chen, Jingfang Mu, Kangping Zhou, Yuming Zhang et autres

Infections caused by coronaviruses are persistent threats to human health in recent decades, necessitating the development of innovative anti-coronaviral therapies. RNA interference (RNAi) is a conserved cell-intrinsic antiviral mechanism in diverse eukaryotic organisms, including mammals. To counteract, many viruses encode viral suppressors …

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Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L

Weilong Deng, Xiao Hu, Xiaoman Tian, Yuanyuan Zhang et autres

Cathepsin L (CatL) is a promising antiviral drug target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an important protease for cleaving the SARS-CoV-2 spike protein and enhancing viral entry to cells. We identified a tripeptide aldehyde candidate, D1–1, which exhibited …

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Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

Xiangrui Jiang, Haixia Su, Weijuan Shang, Feng C. Zhou et autres

Abstract The persistent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants accentuates the great demand for developing effective therapeutic agents. Here, we report the development of an orally bioavailable SARS-CoV-2 3C-like protease …

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A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir

Yumin Zhang, Yuan Sun, Yuanchao Xie, Weijuan Shang et autres

During the ongoing pandemic, providing treatment consisting of effective, low-cost oral antiviral drugs at an early stage of SARS-CoV-2 infection has been a priority for controlling COVID-19. Although Paxlovid and molnupiravir have received emergency approval from the FDA, some side effect concerns …

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In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2

Weijuan Shang, Wenhao Dai, Cheng Yao, Ling Xu et autres

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Visualizing lymphocytic choriomeningitis virus infection in cells and living mice

Yuxi Wen, Huan Xu, Weiwei Wan, Weijuan Shang et autres

Mammarenavirus are a large family of enveloped negative-strand RNA viruses that include several agents responsible for severe hemorrhagic fevers. Until now, no FDA-licensed drug has been admitted for treating an arenavirus infection, and only few effective anti-arenavirus drugs have been tested in …

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Author Correction: Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Xiaodong Luan, Bin-xian Chen, Weijuan Shang, Wanchao Yin et autres

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Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Xiaodong Luan, Bin-xian Chen, Weijuan Shang, Wanchao Yin et autres

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Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

Ruxue Zhang, Yumin Zhang, Wei Zheng, Weijuan Shang et autres

Respiratory syncytial virus (RSV) is the leading cause of serious lower respiratory tract disease in children under 5 years of age worldwide, causing an estimated 3.2 million hospitalizations and 120,000 deaths in children globally per year. Furthermore, nearly all children can be …

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