Hanni Willenbrock

Therapeutic Potential of Neural Rosette Stem Cell-Derived Small Extracellular Vesicles in the Management of Brain Edema

Signe Emilie Dannulat Frazier, Kåre Kryger Vøls, Carlos Romero Quintana, F Nielsen et autres

Abstract Small extracellular vesicles (sEVs) derived from neural stem cells (NSCs) have gained significant interest for their potential roles in neuroprotection, brain edema management, and the preservation of blood-brain barrier (BBB) integrity. These nanoscale particles facilitate intercellular communication and carry a diverse …

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Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Laura Baqué-Vidal, Heather Main, Sandra Petrus-Reurer, Alex R. Lederer et autres

BACKGROUND AIMS: Age-related macular degeneration (AMD) is the most common cause of blindness in elderly patients within developed countries, affecting more than 190 million worldwide. In AMD, the retinal pigment epithelial (RPE) cell layer progressively degenerates, resulting in subsequent loss of photoreceptors …

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Process Development and Manufacturing: RELEASE TESTING OF GMP MANUFACTURED CELLTHRPE1 FOR TREATMENT OF DRY AGE-RELATED MACULAR DEGENERATION

Laura Vidal, Hilary C. Main, H.J. Reilly, Mona Hedenskog et autres

Endothelial Cell Insulin Signaling Regulates CXCR4 (C-X-C Motif Chemokine Receptor 4) and Limits Leukocyte Adhesion to Endothelium

Thomas Rathjen, Britta H. Kunkemoeller, Carly Cederquist, Xuanchun Wang et autres

BACKGROUND: An activated, proinflammatory endothelium is a key feature in the development of complications of obesity and type 2 diabetes and can be caused by insulin resistance in endothelial cells. METHODS: We analyzed primary human endothelial cells by RNA sequencing to discover …

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Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

Sandra Petrus-Reurer, Alex R. Lederer, Laura Baqué-Vidal, Iyadh Douagi et autres

Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular states during in vitro differentiation has not been performed. Here, we …

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Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473

Khanh‐Van Tran, Erin L. Brown, Tiffany DeSouza, Naja Zenius Jespersen et autres

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Semaglutide lowers body weight in rodents via distributed neural pathways

Sanaz Gabery, Casper Graversen Salinas, Sarah Juel Paulsen, Jonas Ahnfelt‐Rønne et autres

Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP-1Rs) in the brain. The findings presented here show that …

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A long-non-coding RNA, LINC00473 , confers the human adipose tissue thermogenic phenotype through enhanced cAMP responsiveness

Khanh‐Van Tran, Cecilie Nandrup-Bus, Tiffany DeSouza, Ricardo Soares et autres

Summary Specialized adipocytes localized in distinct depots mediate the many physiological functions of adipose tissue. In humans, paucity of thermogenic adipocytes correlates with high metabolic disease risk, raising much interest in the mechanisms by which these cells arise. Here we report molecular …

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The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbæk Wolf, Lars Groth Grunnet et autres

OBJECTIVE: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screening platform for identification …

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MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma

Nicolai A. Schultz, Jens Werner, Hanni Willenbrock, Anne Roslind et autres

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Prognostic MicroRNAs in Cancer Tissue from Patients Operated for Pancreatic Cancer—Five MicroRNAs in a Prognostic Index

Nicolai A. Schultz, Klaus Kaae Andersen, Anne Roslind, Hanni Willenbrock et autres

BACKGROUND: The aim of the present study was to identify a panel of microRNAs (miRNAs) that can predict overall survival (OS) in non micro-dissected cancer tissues from patients operated for pancreatic cancer (PC). METHODS: MiRNAs were purified from formalin-fixed paraffin embedded (FFPE) …

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Validation of a plasma-based miRNA PCR test for early detection of colorectal cancer.

Søren Jensby Nielsen, Hanni Willenbrock, Jacob U. Fog, Jan Stenvang et autres

424 Background: Colorectal cancer (CRC) is a major cause of mortality in the western world. Early detection of CRC improves survival and screening for CRC has been clinically proven to lower CRC-related mortality in the screening population. However, although population screening programs …

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