Fredrik Wolfhagen Sand

Prevalence and importance of coronary microvascular dysfunction in patients with heart failure and reduced or mildly reduced ejection fraction

Charlotte Nordberg Backelin, Sara Svedlund, Entela Bollano, Clara Hjalmarsson et autres

AIMS: We investigated the prevalence of coronary microvascular dysfunction (CMD) and its association with severity of heart failure in patients with reduced or mildly reduced ejection fraction (HFrEF and HFmrEF). METHOD: Patients with stable, symptomatic heart failure with left ventricular ejection fraction …

se, in, fi, it, nl, gb, sg (code pays fourni par la source)

Coronary microvascular dysfunction in patients with heart failure with reduced and mildly reduced ejection fraction: results from the PANACEA study

Charlotte Nordberg Backelin, Sara Svedlund, Entela Bollano, Claes Hjalmarsson et autres

Abstract Aims Coronary microvascular dysfunction (CMD) is common and associated with impaired survival in patients with heart failure with preserved ejection fraction (HFpEF). In patients with heart failure with reduced ejection fraction (HFrEF) and mildly reduced ejection fraction (HFmrEF) the impact of …

se, br, us (code pays fourni par la source)

966-P: Machine Learning Applied to Digital Retinal Images to Predict Glycated Haemoglobin

Victoria Parker, Nils Svangård, VIKNESH SELVERAJAH, TOM WHITE et autres

Background: Machine-learning (ML) applied to retinal images can be used to make predictions of age, gender, retinopathy diagnosis and HbA1c. We sought to evaluate this technology in a setting with more limited healthcare infrastructure. Methods: Using UK Biobank data we used machine-learning …

Optimising streptozotocin dosing to minimise renal toxicity and impairment of stomach emptying in male 129/Sv mice

Sisse A Nørgaard, Henrik Søndergaard, Dorte Bratbo Sørensen, Elisabeth D. Galsgaard et autres

The streptozotocin (STZ)-induced diabetic mouse model has been extensively used as a model for diabetes and diabetic nephropathy, but it is still influenced by many off-target toxic effects and large variation in diabetes induction. Therefore, the aim of this study was to …

dk (code pays fourni par la source)

Nephropathy in diabetic db/db mice is accelerated by high protein diet and improved by the SGLT2 inhibitor dapagliflozin

Sisse A Nørgaard, François Briand, Fredrik Wolfhagen Sand, Elisabeth D. Galsgaard et autres

dk, fr (code pays fourni par la source)

Softened food reduces weight loss in the streptozotocin-induced male mouse model of diabetic nephropathy

Sisse A Nørgaard, Fredrik Wolfhagen Sand, Dorte Bratbo Sørensen, Klas Abelson et autres

The streptozotocin (STZ)-induced diabetic mouse is a widely used model of diabetes and diabetic nephropathy (DN). However, it is a well-known issue that this model is challenged by high weight loss, which despite supportive measures often results in high euthanization rates. To …

dk (code pays fourni par la source)

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

Duo An, Alan Chiu, James A. Flanders, Wei Song et autres

-releasing nanoporous polymer thread that promoted uniform in situ cross-linking and strong adhesion of a thin layer of alginate hydrogel around the thread. The device provided immunoprotection of rat islets in immunocompetent C57BL/6 mice in a short-term (1-mo) study, similar to neat …

us, dk, cn (code pays fourni par la source)

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbæk Wolf, Lars Groth Grunnet et autres

OBJECTIVE: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screening platform for identification …

dk, us, fi, gb, fr (code pays fourni par la source)

N-CAM Exhibits a Regulatory Function in Pathological Angiogenesis in Oxygen Induced Retinopathy

Joakim Håkansson, Anders Ståhlberg, Fredrik Wolfhagen Sand, Holger Gerhardt et autres

BACKGROUND: Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion …

se, gb (code pays fourni par la source)

Growth-limiting role of endothelial cells in endoderm development

Fredrik Wolfhagen Sand, Andreas Hörnblad, Jenny K. Johansson, Christina E. Lorén et autres

se (code pays fourni par la source)

A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures

Simin Rymo, Holger Gerhardt, Fredrik Wolfhagen Sand, Richard A. Lang et autres

BACKGROUND: Myeloid cells have been associated with physiological and pathological angiogenesis, but their exact functions in these processes remain poorly defined. Monocyte-derived tissue macrophages of the CNS, or microglial cells, invade the mammalian retina before it becomes vascularized. Recent studies correlate the …

se, gb, us (code pays fourni par la source)

ENDOTHELIAL- EPITHELIAL INTERACTIONS Blood vessels friends or foes?

Fredrik Wolfhagen Sand

Diabetes affects enormous amounts of patients. In type 1 diabetes the insulin producing β cells in the islet of Langerhans are destroyed by the immune system. The β cells, which are located in the pancreas, regulate blood glucose levels. The lack of …