Arginine metabolism supports metabolic reprogramming in trained immunity
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Le résumé fourni par la source
Trained immunity, also termed innate immune memory, is supported by the metabolic rewiring of innate immune cells, altering their bioenergetic profile and ultimately their functions. While amino acids such as arginine are known to possess immunomodulatory properties, their role in trained immunity remains largely unexplored. Primary human monocytes were trained with β-glucan in a medium enriched with or deprived of arginine or supplemented with an arginase inhibitor. After a resting period, trained cells were restimulated with LPS. Arginine deprivation or arginase inhibition during β-glucan training impaired the amplification of IL-6 and TNF cytokine response to LPS, while they did not affect the cells' phagocytotic capacity. Arginine deprivation also significantly reduced the oxygen consumption rate of trained cells, without affecting glycolysis. Genetic studies revealed polymorphisms near genes coding for arginine-metabolizing enzymes modulated the induction of trained immunity, highlighting the role of arginine-derived metabolites in trained immunity. These findings demonstrate that arginine and its metabolites are involved in the induction of trained immunity. Understanding metabolic mechanisms involved in trained immunity could provide insights into new therapeutic strategies for harnessing arginine deprivation to modulate inflammatory disorders.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Arginine metabolism supports metabolic reprogramming in trained immunity
- Date Crossref
- 04/06/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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University Medical Center Department of Internal Medicine and Radboud Center for Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Radboud University Medical Center pays non établi dans la noticeOrganisme public
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Radboud Institute for Molecular Life Sciences pays non établi dans la noticeStructure de recherche
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Leiden University Medical Center pays non établi dans la noticeOrganisme public
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Netherlands Metabolomics Centre pays non établi dans la noticeStructure de recherche
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Iuliu Hațieganu University of Medicine and Pharmacy Department of Medical Genetics pays non établi dans la noticeUniversité ou école supérieure
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University of Bonn Department for Immunology and Metabolism pays non établi dans la noticeUniversité ou école supérieure
Radboud University Nijmegen, Department of Internal Medicine and Radboud Center for Infectious Diseases — University Medical Center et Radboud University Medical Center, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.