Bacillus Calmette–Guérin-induced trained immunity potentiates TH17 responses in vitro
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Le résumé fourni par la source
Trained immunity amplifies innate immune responses in an antigen-independent manner. This study explored the ability of trained human primary macrophages to modulate the phenotype and function of T cells. Macrophages play an important role in antigen presentation, resulting in T-cell activation and antigen-specific clonal expansion; however, few studies have investigated whether trained immunity induction in macrophages modulates T-cell activation. Here, through surface marker analysis of naive, β-glucan-, and Bacillus Calmette-Guérin-trained macrophages, we identified 8 distinct macrophage clusters following trained immunity induction. One of these populations showed an increase in surface activation markers CD40 and CD86, as well as major histocompatibility complex molecules. In vitro co-culture of T cells with autologous Bacillus Calmette-Guérin-trained macrophages resulted in a skewing toward TH17 cells. We also observed an increase in TH17 percentage after Bacillus Calmette-Guérin vaccination of human subjects. The bias toward TH17 triggered by trained macrophages required direct T cell to macrophage contact. Trained macrophages potentiated TH17 skewing independently of the antigen presented. While co-cultures of T cells and Bacillus Calmette-Guérin-trained macrophages responded with higher production of interferon-γ and interleukin-17 after stimulation, no clear shifts toward effector or memory T cells were observed. In conclusion, this study provides evidence that Bacillus Calmette-Guérin-trained macrophages can modulate T-cell function toward a TH17 phenotype, suggesting that Bacillus Calmette-Guérin-induced trained immunity has the potential to enhance not only innate immune responses but also to modify adaptive T-cell immunity.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Bacillus Calmette–Guérin-induced trained immunity potentiates TH17 responses in vitro
- Date Crossref
- 29/08/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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University Medical Center Department of Anesthesiology pays non établi dans la noticeÉtablissement de santé
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Radboud University Medical Center pays non établi dans la noticeOrganisme public
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Radboud Institute for Molecular Life Sciences pays non établi dans la noticeStructure de recherche
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Austrian Academy of Sciences pays non établi dans la noticeOrganisme public
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CeMM Research Center for Molecular Medicine pays non établi dans la noticeStructure de recherche
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Iuliu Hațieganu University of Medicine and Pharmacy Department of Medical Genetics pays non établi dans la noticeUniversité ou école supérieure
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University of Bonn Department for Immunology and Metabolism pays non établi dans la noticeUniversité ou école supérieure
Radboud University Nijmegen, Department of Anesthesiology — University Medical Center et Radboud University Medical Center, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.