Darren Pavey

The delivered dose assessment in pancreas SBRT with the target position determined using an in-house position monitoring system

Sankar Arumugam, Tony Young, Meredith Johnston, Darren Pavey et autres

Purpose: This study assessed the delivered dose accuracy in pancreas SBRT by incorporating the real-time target position determined using an in-house position monitoring system. Methods and materials: An online image-based position monitoring system, SeedTracker, was developed to monitor radiopaque marker positions using …

au (code pays fourni par la source)

Barrett’s esophagus with low-grade dysplasia: high rate of upstaging at Barrett’s esophagus referral units suggests progression rates may be overestimated

Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard A. Williams et autres

au (code pays fourni par la source)

The first real-time intrafraction target position monitoring in pancreas SBRT on an Elekta linear accelerator

Sankar Arumugam, Darren Pavey, Andrew Oar, Lois Holloway et autres

au (code pays fourni par la source)

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Vanessa Lakis, Rita T. Lawlor, Felicity Newell, Ann‐Marie Patch et autres

Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with distinct patterns of methylation. The T1 subgroup was enriched for …

au, it, gb, de, us (code pays fourni par la source)

Human papillomavirus infection in esophageal squamous cell carcinoma and esophageal adenocarcinoma: a concise review

Shanmugarajah Rajendra, Darren Pavey, Owen McKay, Neil D. Merrett et autres

The causal link between high-risk human papillomavirus (hr-HPV) infection and cervical, anogenital, and some oropharyngeal malignancies has been established by both molecular and epidemiological data. The association between HPV and esophageal squamous cell carcinoma (ESCC) remains controversial, as is the true prevalence …

au (code pays fourni par la source)

An Australian Three-Centre Feasibility Study of Neoadjuvant Modified FOLFIRINOX and Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer with Collection of Baseline Circulating Tumor Cells

N.J. Collier, Andrew Oar, Weng Ng, Meredith Johnston et autres

au (code pays fourni par la source)

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Stephan B. Dreyer, Rosanna Upstill‐Goddard, Viola Paulus-Hock, Clara Paris et autres

BACKGROUND & AIMS: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage …

gb, fr, us, de, au (code pays fourni par la source)

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosanna Upstill‐Goddard et autres

Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classical (pancreatic) and squamous. We find that these two subtypes are driven by distinct metabolic phenotypes. Loss of genes that drive endodermal lineage specification, HNF4A …

gb, ch, us, de, au (code pays fourni par la source)

Antibodies against human papillomavirus proteins in Barrett's dysplasia and intramucosal esophageal adenocarcinoma

Shanmugarajah Rajendra, Wei Xuan, Katrin Hufnagel, Prateek Sharma et autres

High-risk human papillomavirus (HPV) types 16/18 have been associated with Barrett's dysplasia (BD)/esophageal adenocarcinoma (EAC). Nevertheless, no data exist in relation to serological analysis for HPV antibodies in BD/EAC with site-specific viral DNA status. We prospectively examined antibodies to multiple HPV types …

au, de, us (code pays fourni par la source)

Association of Biomarkers for Human Papillomavirus With Survival Among Adults With Barrett High-grade Dysplasia and Esophageal Adenocarcinoma

Shanmugarajah Rajendra, Preeti Sharma, Shweta Dutta Gautam, Manoj Saxena et autres

IMPORTANCE The presence of high-risk human papillomavirus (HPV) has been associated with a favorable outcome in Barrett high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC).Nevertheless, the prognostic significance of other HPV-related biomarkers (ie, retinoblastoma protein [pRb], cyclin D1 [CD1], minichromosome maintenance protein [MCM2] …

au, us (code pays fourni par la source)

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Claire Vennin, Pauline Mélénec, Romain Rouet, Max Nobis et autres

Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression. Here, we interrogate how cancer cells harboring distinct alterations in p53 manipulate CAFs. We reveal the existence of a p53-driven hierarchy, where cancer …

au, nl, gb, us, it (code pays fourni par la source)

Survival Rates for Patients With Barrett High-grade Dysplasia and Esophageal Adenocarcinoma With or Without Human Papillomavirus Infection

Shanmugarajah Rajendra, Wei Xuan, Neil D. Merrett, Preeti Sharma et autres

Importance: High-risk human papillomavirus (HPV) has been associated with Barrett dysplasia and esophageal adenocarcinoma. Nevertheless, the prognostic significance of esophageal tumor HPV status is unknown. Objective: To determine the association between HPV infection and related biomarkers in high-grade dysplasia or esophageal adenocarcinoma …

au, us (code pays fourni par la source)