Antibodies against human papillomavirus proteins in Barrett's dysplasia and intramucosal esophageal adenocarcinoma
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Le résumé fourni par la source
High-risk human papillomavirus (HPV) types 16/18 have been associated with Barrett's dysplasia (BD)/esophageal adenocarcinoma (EAC). Nevertheless, no data exist in relation to serological analysis for HPV antibodies in BD/EAC with site-specific viral DNA status. We prospectively examined antibodies to multiple HPV types in 438 patients representing hospital/reflux controls and Barrett's metaplasia (BM)/BD/intramucosal EAC. Antibody responses to HPV6/11/16/18/31/33/45/52/58 were analyzed using multiplex serology, including antibodies to E6/E7/E1/E2 and L1 antigens. Seropositivity for individual HPV proteins was infrequent in both cases and controls and was ≤10.2%. There was no difference in the seroprevalence of antibodies to any HPV antigen/antibody combination between reclassified cases (BD/EAC) and controls (hospital/reflux/BM) or between HPV16 or HPV18 DNA cases and controls, respectively. Among HPV16 DNA-positive BD/EAC cases, antibodies to HPV16 E7 were significantly more prevalent (3/26, 11.5%) than in hospital and reflux controls plus BM (5/328, 1.5%) (adjusted OR = 10.12, 95% CI: 1.61-63.73, P = 0.014). Among HPV18 DNA-positive cases, antibodies to HPV18 E1 were present in 3/6 (50%) cases versus 5/328 (1.5%) controls (adjusted OR = 44.28, 95% CI: 6.10-321.47, P = 0.0002). Although antibodies against HPV were generally uncommon in cases and controls, immune responses against two early proteins of HPV16/18 were significantly more frequent in viral DNA-positive BD/intramucosal EAC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Antibodies against human papillomavirus proteins in Barrett's dysplasia and intramucosal esophageal adenocarcinoma
- Date Crossref
- 13/03/2020
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Bankstown Lidcombe Hospital Department of Gastroenterology & Hepatology pays non établi dans la noticeÉtablissement de santé
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UNSW Sydney pays non établi dans la noticeUniversité ou école supérieure
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Ingham Institute Gastro-Intestinal Viral Oncology Group pays non établi dans la noticeOrganisation à but non lucratif
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German Cancer Research Center Infection pays non établi dans la noticeStructure de recherche
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Heidelberg University pays non établi dans la noticeUniversité ou école supérieure
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University of Kansas Division of Gastroenterology and Hepatology pays non établi dans la noticeUniversité ou école supérieure
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Kansas City VA Medical Center pays non établi dans la noticeÉtablissement de santé
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Bankstown‐Lidcombe Hospital South Western Sydney Local Health Network Department of Gastroenterology & pays non établi dans la noticeÉtablissement de santé
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South Western Sydney Clinical School University of New South Wales Kensington New South Wales Australia South Western Sydney Clinical School pays non établi dans la noticeUniversité ou école supérieure
Department of Gastroenterology & Hepatology — Bankstown Lidcombe Hospital, UNSW Sydney et Gastro-Intestinal Viral Oncology Group — Ingham Institute, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.