Jeffrey M. Zigman

Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity

Sepideh Sheybani-Deloui, Kripa Shankar, Angie L. Bookout, Juan A. Rodriguez et autres

The transcriptional landscape of the gastric mucosa in response to opposing nutritional states remains poorly defined. Here, we profiled gastric mucosal gene expression changes induced by diet-induced obesity (DIO) and calorie restriction (CR) in mice and investigated the physiological role of Decidual …

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MOPRs in mouse islets of Langerhans modulate cell signaling and secretion

Michael P. Keith, Diego De Gregorio, Andy Huang, Shannon Townsend et autres

Most clinically and recreationally used opioids drugs act on the endogenous mu opioid receptor (MOPR). While MOPR is typically studied in the context of addiction and analgesia, decades of evidence indicates that they have a strong modulatory role on metabolism and glycemia. …

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From Sideshow to Center Stage: Targeting the Ghrelin System Belongs in the Big Tent of Obesity Therapeutics

Jeffrey M. Zigman

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GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice

Romana Stark, Jeffrey M. Zigman, Zane B. Andrews

Abstract The olfactory bulb (OB) is an emerging neuroendocrine centre regulating appetite, metabolism, and behaviours such as those linked to anxiety, motivation and spatial navigation. These processes are likely mediated by one or more of the many hormone receptors found in the …

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Author response for " GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice"

Romana Stark, Jeffrey M. Zigman, Zane B. Andrews

Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons

Omprakash Singh, Sepideh Sheybani-Deloui, S K Kulkarni, Bing Li et autres

Food consumption impacts body weight differently depending on the time of day. Here, we investigated whether suprachiasmatic nucleus (SCN) neurons responsive to the hormone ghrelin temporally regulate eating and body weight in mice. The chemogenetic stimulation of GHSR (growth hormone secretagogue receptor)-expressing …

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Author response for " GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice"

Romana Stark, Jeffrey M. Zigman, Zane B. Andrews

Meal-feeding promotes skeletal growth by ghrelin-dependent enhancement of growth hormone rhythmicity

Amanda K. E. Hornsby, Richard C. D. Brown, Thomas W Tilston, Harry Smith et autres

The physiological effect of ultradian temporal feeding patterns remains a major unanswered question in nutritional science. We have used automated and nasogastric feeding to address this question in male rodents and human volunteers. While grazing and meal-feeding reduced food intake in parallel …

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Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain

Camila Saenz, Gimena Fernández, Ramiro E. Llovera, María José Tolosa et autres

The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, such as energy homeostasis, appetite control, reward, and stress responses. GHSR mediates the effects …

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RNAi Knockdown of EHMT2 in Maternal Expression of Prader–Willi Syndrome Genes

Violeta Zaric, Hye Ri Kang, Volodymyr Rybalchenko, Jeffrey M. Zigman et autres

Background/objectives: Euchromatic histone lysine methyltransferase 2 (EHMT2, also known as G9a) is a mammalian histone methyltransferase that catalyzes the dimethylation of histone 3 lysine 9 (H3K9). On human chromosome 15, the parental-specific expression of Prader–Willi Syndrome (PWS)-related genes, such as SNRPN and …

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The LEAP2 Response to Cancer-Related Anorexia-Cachexia Syndrome in Male Mice and Patients

Salil Varshney, Kripa Shankar, Haiming L Kerr, Lindsey Anderson et autres

The hormone ghrelin serves a protective role in cancer-related anorexia-cachexia syndrome (CACS)-a condition in which plasma levels of ghrelin rise, its administration lessens CACS severity, and experimentally reduced signaling by its receptor (GHSR) worsens fat loss and anorexia and accelerates death. Yet, …

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Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism

Romana Stark, Harry Dempsey, Elizabeth A. Kleeman, Martina Sassi et autres

Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increase olfactory function and influence foraging behaviors and …

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