Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
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Le résumé fourni par la source
Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs) in the olfactory bulb (OB) increase olfactory function and influence foraging behaviors and metabolism. We performed a detailed behavioural and metabolic analysis in mice lacking GHSRs in the OB (OBGHSR deletion). We also analsyed OB scRNA-seq and spatial transcriptomic datasets to assess GHSR+ cells in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus. OBGHSR deletion affected olfactory discrimination and habituation to both food and non-food odors. Anxiety-like and depression-like behaviors were significantly greater after OBGHSR deletion, whereas exploratory behavior was reduced, with the greatest effect under fasted conditions. OBGHSR deletion impacted feeding behavior as evidenced by altered bout number and duration, as well as buried food-seeking. OBGHSR deletion increased body weight and fat mass, spared fat utilisation on a chow diet and impaired glucose metabolism indicating metabolic dysfunction. Cross referenced analysis of OB scRNA-seq and spatial transcriptomic datasets revealed GHSR+ glutamate neurons in the main and accessory olfactory bulbs, as well as the anterior olfactory nucleus. Ablation of glutamate neurons in the OB reduced ghrelin-induced food finding and phenocopied results seen after OBGHSR deletion. OBGHSRs help to maintain olfactory function, particularly during hunger, and facilitate behavioral adaptations that optimise food-seeking in anxiogenic environments, priming metabolic pathways in preparation for food consumption.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism
- Date Crossref
- 01/11/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Discovery Institute pays non établi dans la noticeOrganisation à but non lucratif
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Australian Regenerative Medicine Institute pays non établi dans la noticeStructure de recherche
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Monash University Monash Biomedicine Discovery Institute and Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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Florey Institute of Neuroscience and Mental Health pays non établi dans la noticeStructure de recherche
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Swansea University pays non établi dans la noticeUniversité ou école supérieure
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Southwestern Medical Center Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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The University of Texas Southwestern Medical Center pays non établi dans la noticeÉtablissement de santé
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School of Medicine Institute of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
Discovery Institute, Australian Regenerative Medicine Institute et Monash Biomedicine Discovery Institute and Department of Physiology — Monash University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.