María José Tolosa

AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice

Daniela Cassano, Franco Barrile, Mirta Reynaldo, Gimena Fernández et autres

Hunger enhances the consumption of rewarding foods, but the neurobiological basis of this adaptation remains unclear. We hypothesize that agouti-related protein (AgRP) neurons in the hypothalamic arcuate nucleus (ARH) promote the consumption of rewarding stimuli under calorie restriction, independent of caloric content. …

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Mini-ghrelins: Functional Characterization of N-terminal Peptides Derived From Ghrelin Proteolysis in Male Samples

Gimena Fernández, Antonela S. Fittipaldi, Daniela Lufrano, Emilio Román Mustafá et autres

Some evidence suggests that ghrelin in plasma undergoes proteolytic processing, leading to the generation of shorter peptides containing the bioactive N-terminal end of this peptide hormone. However, the chemical nature and bioactivity of these shorter versions of ghrelin (termed mini-ghrelins) remain to …

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Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain

Camila Saenz, Gimena Fernández, Ramiro E. Llovera, María José Tolosa et autres

The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, such as energy homeostasis, appetite control, reward, and stress responses. GHSR mediates the effects …

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Comunicación entre células

Ignácio E. León, María José Tolosa, Pablo Mobili

La capacidad de las células de recibir, procesar y enviar información entre ellas, les permite a los organismos multicelulares responder eficientemente a cambios en el medio externo o en el medio interno, de manera tal de mantener la homeostasis. En un organismo …

Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor–dependent manner

Agustina Cabral, Gimena Fernández, María José Tolosa, Ángeles Rey Moggia et autres

Arcuate nucleus (ARC) neurons producing Agouti-related peptide (AgRP) and neuropeptide Y (NPY; ARCAgRP/NPY neurons) are activated under energy-deficit states. ARCAgRP/NPY neurons innervate the hypothalamic paraventricular nucleus (PVH), and ARC→PVH projections are recognized as key regulators of food intake. Plasma ghrelin levels increase …

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Axonal fiber quantification in fluorescence images

Pablo Nicolás De Francesco, María José Tolosa

A set of Fiji macros for axonal fiber quantification in fluorescence images. These macros were developed for the study: Fasting Induces Remodeling Of The Orexigenic Projections From The Arcuate Nucleus To The Hypothalamic Paraventricular Nucleus, In A Growth Hormone Secretagogue Receptor-Dependent Manner …

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Ghrelin receptor signaling in dopamine neurons mediates high fat intake in a binge eating model

María Paula Cornejo, Franco Barrile, Guadalupe García Romero, Daniela Cassano et autres

Ghrelin is a peptide hormone secreted by endocrine cells located in the stomach fundus.It regulates a variety of biological processes, including energy homeostasis.Ghrelin administration to humans and rodents induces food intake.The orexigenic effects of ghrelin are mainly due to its action in …

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Melanocortin 4 receptor constitutive activity inhibits L-type voltage-gated calcium channels in neurons

Francina Agosti, Santiago Cordisco González, Valentina Martínez Damonte, María José Tolosa et autres

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Efecto de drogas antidiabéticas sobre la diferenciación de células progenitoras de médula ósea y la microarquitectura de tejido óseo de rata

María José Tolosa

Objetivos generales: a) Evaluar los efectos in vivo, ex vivo e in vitro de drogas antidiabéticas (metformina y/o rosiglitazona) sobre la diferenciación de CPMO y la microarquitectura ósea de ratas control. b) Investigar el efecto in vivo y ex vivo del tratamiento …

Insulin-deficient diabetes-induced bone microarchitecture alterations are associated with a decrease in the osteogenic potential of bone marrow progenitor cells: Preventive effects of metformin

María José Tolosa, Sara Chuguransky, Claudia Sedlinsky, León Schurman et autres

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La diabetes altera el potencial osteogénico de células progenitoras de médula ósea: Efectos del tratamiento con metformina

María José Tolosa, Sara Chuguransky, León Schurman, Claudia Sedlinsky et autres

En este trabajo, estudiamos el efecto de una Diabetes inducida por destrucción parcial de la masa de células beta pancreáticas, sobre el compromiso osteogénico de células progenitoras de médula ósea (CPMO), y su modulación por el tratamiento oral con Metformina. Para ello …

Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats

Claudia Sedlinsky, María Silvina Molinuevo, Ana Marı́a Cortizo, María José Tolosa et autres

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