Alaa Tayyib

Genetics of Cataract

Alaa Tayyib, Jagadeesan Madhavan, Elise Héon

Abstract Cataract affects all ages, sexes, and populations. Mendelian cataract is usually of early onset, with or without a family history. The term “congenital/infantile cataract” refers to lens opacities that present at birth or are detected in the first year of life. …

Molecular Genetics of Closed-Angle Glaucoma

Élise Héon, Kavin Selvan, Alaa Tayyib, Ajoy Vincent

Abstract Primary angle-closure glaucoma (PACG) is a complex group of conditions with many contributing factors, including genetic predisposition. PACG is characterized by elevated intraocular pressure (IOP) and closure of the iridocorneal angle of at least 180 degrees. Sex and racial differences are …

Insights into the effects of subretinal voretigene neparvovec-rzyl in RPE65-associated Leber congenital amaurosis

Alaa Tayyib, Deepika Chennapura Parameswarappa, Peter J. Kertes, Rajeev H. Muni et autres

OBJECTIVE: Assess safety and effectiveness of subretinal gene replacement therapy at 18 months post treatment. DESIGN: Retrospective, longitudinal study conducted at the Hospital for Sick Children in Toronto, Canada. PARTICIPANTS: Patients with bi-allelic RPE65 variants, early onset retinal degeneration, and residual viable …

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Characterising the refractive error in paediatric patients with congenital stationary night blindness: a multicentre study

Austin D. Igelman, Elizabeth White, Alaa Tayyib, Lesley A Everett et autres

Background/Aaims Congenital stationary night blindness (CSNB) is an inherited retinal disease that is often associated with high myopia and can be caused by pathological variants in multiple genes, most commonly CACNA1F , NYX and TRPM1 . High myopia is associated with retinal …

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Deep phenotypic characterization of the retinal dystrophy in patients with RNU4ATAC-associated Roifman syndrome

Brian G. Ballios, Amarilla Bernadett Mandola, Alaa Tayyib, Anupreet K. Tumber et autres

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Genetics of retinal degeneration in 2023

Elise Héon, Ajoy Vincent, Alaa Tayyib

Inherited retinal degenerations (IRDs) are of great interest with the development of novel therapies, thereby allowing this group of conditions to be “actionable” for the first time. A molecular diagnosis can be obtained in nearly 70% of cases of IRD, with over …

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Effects of Early Treatment of Retinopathy of Prematurity at a Tertiary Care Hospital in Saudi Arabia: A Retrospective Study

Enam Danish, Manal Taha Hadrawi, Alaa Tayyib, Rafaa Babgi

Purpose: To estimate the prevalence of retinopathy of prematurity (ROP) among high-risk neonates and to illuminate the benefits of early treatment in type 2 ROP (zone II, stage 3 without plus) and ROP milder than type 1 with pre-plus disease (zone III, …

Peters Anomaly in Twins: A Case Report of a Rare Incident with Novel Comorbidities

Hashem Almarzouki, Alaa Tayyib, Hassan A. Khayat, Saeed Mohammed Al-Zahrani et autres

INTRODUCTION: Peters anomaly is a rare developmental malformation involving the anterior segment of the eye, which culminates in amblyopia or congenital blindness. Multiple ocular and/or systemic malformations have been observed with this anomaly, and novel comorbidities continue to be reported. CASE PRESENTATION: …

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Peter's anomaly in twins: a rare incidence with novel associations

Hassan A. Khayat, Alaa Tayyib, Raed E. Alsulami, A. alkahtani et autres

Purpose Peter's anomaly is a rare developmental malformation involving the anterior segment of the eye culminating in congenital blindness, with or without systemic associations. herein, we report an incidence of this anomaly in twins with novel associations. Methods Chart review, clinical and …

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