Lauren Buckley

Estimated Foetal Weight Versus Abdominal Circumference in Predicting Adverse Outcome in Foetal Growth Restriction

Lydia P. DeAngelo, Justin Moore, Meng Yao, Catherine Klammer et autres

ABSTRACT Objective To identify foetal growth restriction (FGR) based on estimated foetal weight (EFW) < 10th percentile, abdominal circumference (AC) < 10th percentile or both EFW and AC < 10th percentile. To determine which group(s) is associated with a higher risk for …

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Bewertung der Bioäquivalenz und des Nahrungseffekts einer neuen Tablettenformulierung von Risdiplam bei gesunden Probanden

Željko Uzelac, Heidemarie Kletzl, Katja Heinig, Birgit Jaber et autres

Hintergrund: Risdiplam (EVRYSDI®​) ist zur Behandlung der spinalen Muskelatrophie (SMA) zugelassen. Derzeit ist Risdiplam als Lösung zum Einnehmen, die täglich mittels einer Spritze aufgezogen werden muss, erhältlich. Für Patientinnen≥20 kg und mit der entsprechenden Dosis von 5 mg Risdiplam würde eine bioäquivalente …

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Postpartum Readmission after Unscheduled Cesarean Delivery in Patients with Class 3 Obesity

Surabhi Tewari, Meng Yao, Lydia DeAngelo, Victoria Rogness et autres

Abstract This study aimed to identify risk factors for postpartum readmission (PPR) in class 3 obese patients undergoing unscheduled cesarean deliveries. Retrospective cohort study of patients with a body mass index (BMI) of ≥40 kg/m2 undergoing unscheduled cesarean delivery from 2017 to …

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Inflammation as a Sex-Specific Mediator in the Relationship between Maternal and Offspring Obesity in C57Bl/6J Mice

Lauren Buckley, Debra Kulhanek, Adrienne Bruder, Tate Gisslen et autres

Maternal obesity is a well-established risk factor for offspring obesity development. The relationship between maternal and offspring obesity is mediated in part by developmental programming of offspring metabolic circuitry, including hypothalamic signaling. Dysregulated hypothalamic inflammation has also been linked to development of …

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Real‐world persistence of multiple sclerosis disease‐modifying therapies

Emma Tallantyre, Ruth Dobson, Joseph L. J. Froud, Frederika A. St John et autres

BACKGROUND AND PURPOSE: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability. We aimed to describe real-world rates of persistence on disease-modifying therapies (DMTs) for people with multiple sclerosis (pwMS) and reasons for …

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142 Estimated fetal weight versus abdominal circumference in predicting adverse outcome in fetal growth restriction

Lydia DeAngelo, Justin Moore, Meng Yao, Sarah C. Graves et autres

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Standard-Dose Azithromycin in Class III Obese Patients Undergoing Unscheduled Cesarean Delivery

Maeve Hopkins, Surabhi Tewari, Meng Yao, Lydia DeAngelo et autres

Objective Perioperative antibiotic prophylaxis reduces cesarean wound complications. This study investigates whether integration of standard-dose (500 mg) azithromycin prophylaxis reduced wound complications in patients with class III obesity (body mass index [BMI] ≥ 40 kg/m2) undergoing unscheduled cesarean delivery. Study Design Retrospective …

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Prenatal Genetic Screening in Twin Pregnancy

Lauren Buckley, Maeve Hopkins, Jeffrey A. Kuller, Lorraine Dugoff

Twin pregnancy presents unique considerations for aneuploidy screening. Pre-test counseling regarding benefits, alternatives, and options for aneuploidy screening should be provided to all patients carrying twin pregnancy. This article aims to review the options for aneuploidy screening in twin pregnancy including the …

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Risk factors for postpartum readmission in patients with class III obesity undergoing unscheduled cesarean delivery

Surabhi Tewari, Meng Yao, Lydia DeAngelo, Victoria Rogness et autres

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Fetal chromosomal abnormality and risk to pregnancy

Maeve Hopkins, Lauren Buckley, Sarah K. Dotters‐Katz, Manesha Putra

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Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood

Debra Kulhanek, Juan E. Abrahante, Lauren Buckley, Ivan Tkáč et autres

Offspring exposed to maternal diet-induced obesity demonstrate a phenotype consistent with energy excess. Contrary to previous studies, the observed energy phenotype was not associated with hyperphagia or decreased basal metabolic rate but rather decreased hypothalamic neuronal activity and energy production. This was …

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Impact of Respiratory Syncytial Virus on Child, Caregiver, and Family Quality of Life in the United States: Systematic Literature Review and Analysis

Elizabeth Glaser, Dhwani Hariharan, Diana Bowser, Raíssa M Gervasio et autres

BACKGROUND: Respiratory syncytial virus (RSV), a leading cause of lower respiratory tract infection in US children, reduces quality of life (QOL) of children, their caregivers, and families. METHODS: We conducted a systematic literature review in PubMed, EconLit, and other databases in the …

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