Ivan Tkáč

Synthetic Data in MR Spectroscopy: Current Practices, Applications, and Considerations

John LaMaster, Aaron T. Gudmundson, Alireza Abaei, Şeyma Alçiçek et autres

The use of synthetic data has emerged as an essential tool in Magnetic Resonance Spectroscopy (MRS) research and applications, providing advantages for optimization of acquisition, software validation, deep learning applications, and enhanced reproducibility. Importantly, synthetic data addresses challenges of limited training data …

Synthetic Data in MR Spectroscopy: Current Practices, Applications, and Considerations

John LaMaster, Aaron T. Gudmundson, Alireza Abaei, Şeyma Alçiçek et autres

The use of synthetic data has emerged as an essential tool in Magnetic Resonance Spectroscopy (MRS) research and applications, providing advantages for optimization of acquisition, software validation, deep learning applications, and enhanced reproducibility. Importantly, synthetic data addresses challenges of limited training data …

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Longitudinal study of neurochemical, volumetric and behavioral changes in Q140 & BACHD mouse models of Huntington’s disease

Lori Zacharoff, Ivan Tkáč, Alexander Shapiro, Pierre‐Gilles Henry et autres

Abstract Brain metabolites, detectable by magnetic resonance spectroscopy (MRS), have been examined as potential biomarkers in Huntington’s Disease (HD). In this study, the RQ140 and BACHD transgenic mouse models of HD were used to investigate the relative sensitivity of the metabolite profiling …

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Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla

Ivan Tkáč, Tiankai Xie, Nitya Shah, Sarah N. Larson et autres

Objective To determine sex differences in the neurochemical concentrations measured by in vivo proton magnetic resonance spectroscopy (1H MRS) of healthy mice on a genetic background commonly used for neurodegenerative disease models. Methods 1H MRS data collected from wild type mice with …

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Improved reproducibility of γ‐aminobutyric acid measurement from short‐echo‐time proton MR spectroscopy by linewidth‐matched basis sets in LCModel

Ying Xiao, Bernard Lanz, Song‐I Lim, Ivan Tkáč et autres

Abstract γ‐Aminobutyric acid (GABA), as the primary inhibitory neurotransmitter, is extremely important for maintaining healthy brain function, and deviations from GABA homeostasis are related to various brain diseases. Short‐echo‐time (short‐TE) proton MR spectroscopy (1H‐MRS) has been employed to measure GABA concentration from …

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Animal models using C57BL/6J mice are at risk of data misinterpretation due to random occurrences of animals with high levels of brain glutamine

Ivan Tkáč, Raghavendra Rao, Megan E. Paulsen

Wild-type and transgenic mice derived from the C57BL/6J mouse strain are widely used in animal models of different human diseases. However, this mouse strain suffers from random appearances of sporadic congenital portosystemic shunts resulting in extremely high glutamine levels in the brain. …

Investigating the influences of spectral lineshape and linewidth in LCModel basis-sets on 1H MRS quantification at 7T

Ying Xiao, Ivan Tkáč, Lijing Xin

In this study, we investigated the 1H MR spectra quantification accuracy using basis sets with different linewidths and lineshapes in LCModel. Simulation results showed that the estimated metabolite concentrations depend on the linewidths and lineshapes of the basis sets as well as …

Region-specific effects of neonatal hyperbilirubinemia on the developing brain in a preterm Gunn rat model

Ivan Tkáč, Katherine M. Satrom, Raghavendra Rao

Preterm Gunn rat model of neonatal hyperbilirubinemia (NHB) was used to investigate effects of unconjugated bilirubin (UCB) on the developing hippocampus and cerebellum. In this model, sulfadimethoxine was injected (i.p.) to Gunn rat pups on postnatal day 5 to exaggerate NHB effects …

Neonatal hyperbilirubinemia differentially alters the neurochemical profiles of the developing cerebellum and hippocampus in a preterm Gunn rat model

Katherine M. Satrom, Raghavendra Rao, Ivan Tkáč

Neonatal hyperbilirubinemia (NHB) can lead to brain injury in newborn infants by affecting specific regions including the cerebellum and hippocampus. Extremely preterm infants are more vulnerable to bilirubin neurotoxicity, but the mechanism and extent of injury is not well understood. A preterm …

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Magnetic Resonance Spectroscopy: Clinical Applications

Alena Horská, Adam Berrington, Peter B. Barker, Ivan Tkáč

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Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood

Debra Kulhanek, Juan E. Abrahante, Lauren Buckley, Ivan Tkáč et autres

Offspring exposed to maternal diet-induced obesity demonstrate a phenotype consistent with energy excess. Contrary to previous studies, the observed energy phenotype was not associated with hyperphagia or decreased basal metabolic rate but rather decreased hypothalamic neuronal activity and energy production. This was …

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Intranasal Insulin Attenuates the Long-Term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats

Lauren McClure Yauch, Kathleen Ennis-Czerniak, William H. Frey, Ivan Tkáč et autres

Hyperglycemia due to relative hypoinsulinism is common in extremely preterm infants and is associated with hippocampus-mediated long-term cognitive impairment. In neonatal rats, hypoinsulinemic hyperglycemia leads to oxidative stress, altered neurochemistry, microgliosis, and abnormal synaptogenesis in the hippocampus. Intranasal insulin (INS) bypasses the …

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