Accès ouvert
2026
preprint
OpenAlex
Patrick Keppel, Marek Chovanec, Nikolaus Poremba, Anna Kovalová et autres
The inverse electron-demand Diels–Alder (IEDDA) reaction between tetrazines (Tz) and trans -cyclooctenes (TCO) is among the fastest click reactions known. Although extensively optimized for aqueous environments, its reactivity in organic solvents remains strongly constrained, limiting applications under non-aqueous conditions. Here we report …
at, cz
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Marek Chovanec, Michal Rahm, Patrick Keppel, Milan Vrábel
This file contains all raw NMR data and a decoding, compound numbering sheet to the manuscript entitled: Electrostatic attraction unlocks rapid tetrazine–trans-cyclooctene click chemistry in organic solvents.
cz, at
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Marek Chovanec, Michal Rahm, Patrick Keppel, Milan Vrábel
This file contains all raw NMR data and a decoding, compound numbering sheet to the manuscript entitled: Electrostatic attraction unlocks rapid tetrazine–trans-cyclooctene click chemistry in organic solvents.
cz, at
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Marek Chovanec, Michal Rahm, Jáchym Hrušák, Paul E. Reyes‐Gutiérrez
This file contains a zip of all compounds from the publication: Organelle-Resolved Tetrazine-trans-Cyclooctene Click Chemistry for Cargo Delivery and Release (https://doi.org/10.1002/chem.71198)
cz
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Marek Chovanec, Michal Rahm, Jáchym Hrušák, Paul E. Reyes‐Gutiérrez
This file contains a zip of all compounds from the publication: Organelle-Resolved Tetrazine-trans-Cyclooctene Click Chemistry for Cargo Delivery and Release (https://doi.org/10.1002/chem.71198)
cz
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm et autres
Accurate delivery of small molecules to specific cell compartments or organelles offers great potential for bioimaging and targeted therapy but remains challenging to predict and control. In this study, we evaluate a modular strategy for organelle-directed delivery based on organelle-targeting groups combined …
cz, pl
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Rastislav Dzijak, Simona Bellová, Anna Kovalova, Veronika Šlachtová et autres
ABSTRACT Chemical engineering of cellular surfaces offers a powerful tool to endow cells with new properties and functions, yet methods for adding complex biomolecules to cell membranes remain underdeveloped. While technologies for targeted degradation of cell surface components are advancing, few approaches …
cz
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Kristýna Brejchová, Michal Rahm, Andrea Beňová, Veronika Domanska et autres
OBJECTIVE: Insulin-sensitizing drugs, despite their broad use against type 2 diabetes, can adversely affect bone health, and the mechanisms underlying these side effects remain largely unclear. Here, we investigated the different metabolic effects of a series of thiazolidinediones, including rosiglitazone, pioglitazone, and …
by, cz
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres
Bioorthogonal bond-cleavage reactions enable precise control of (bio)molecular function in biological systems. In their Research Article (e202411707), Hannes Mikula et al. report the development of “yellow” hydroxyaryl-tetrazines as bioorthogonal tools for efficient click-to-release of trans-cyclooctenes. The cover picture illustrates the transformation of …
at, us, pl, cz
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres
Bioorthogonal bond-cleavage reactions enable precise control of (bio)molecular function in biological systems. In their Research Article (e202411707), Hannes Mikula et al. report the development of “yellow” hydroxyaryl-tetrazines as bioorthogonal tools for efficient click-to-release of trans-cyclooctenes. The cover picture illustrates the transformation of …
at, de, us, pl, cz
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Michal Rahm, Patrick Keppel, Veronika Šlachtová, Rastislav Dzijak et autres
Abstract Bioorthogonal reactions that enable switching molecular functions by breaking chemical bonds have gained prominence, with the tetrazine‐mediated cleavage of trans ‐cyclooctene caged compounds (click‐to‐release) being particularly noteworthy for its high versatility, biocompatibility, and fast reaction rates. Despite several recent advances, the …
cz, at
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Michal Rahm, Patrick Keppel, Veronika Šlachtová, Rastislav Dzijak et autres
Abstract Bioorthogonal reactions that enable switching molecular functions by breaking chemical bonds have gained prominence, with the tetrazine‐mediated cleavage of trans ‐cyclooctene caged compounds (click‐to‐release) being particularly noteworthy for its high versatility, biocompatibility, and fast reaction rates. Despite several recent advances, the …
cz, at
(code pays fourni par la source)