Accès ouvert
2026
dataset
OpenAlex
Marek Chovanec, Michal Rahm, Jáchym Hrušák, Paul Eduardo Reyes‐Gutierrez
This file contains a zip of all compounds from the publication: Organelle-Resolved Tetrazine-trans-Cyclooctene Click Chemistry for Cargo Delivery and Release (https://doi.org/10.1002/chem.71198)
cz
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Marek Chovanec, Michal Rahm, Jáchym Hrušák, Paul Eduardo Reyes‐Gutierrez
This file contains a zip of all compounds from the publication: Organelle-Resolved Tetrazine-trans-Cyclooctene Click Chemistry for Cargo Delivery and Release (https://doi.org/10.1002/chem.71198)
cz
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm et autres
Accurate delivery of small molecules to specific cell compartments or organelles offers great potential for bioimaging and targeted therapy but remains challenging to predict and control. In this study, we evaluate a modular strategy for organelle-directed delivery based on organelle-targeting groups combined …
cz, pl
(code pays fourni par la source)
2025
dissertation
OpenAlex
Jáchym Hrušák
The use of fluorogenic probes in fluorescence bioimaging has attracted much attention over the past few decades.1 The introduction of bioorthogonal chemistry by Bertozzi in 20032 provided a new perspective on fluorogenicity and spurred the development of various branches of chemistry and …
2022
dissertation
OpenAlex
Jáchym Hrušák
This bachelor thesis focuses on the design and synthesis of 1,2,4,5-tetrazine and trans- cyclooctene derivatives containing functional moieties which are able to target cellular nucleus and participate in bioorthogonal reactions. Based on literature research, the targeting moieties and the structure of the …