Martin Wilkovitsch

trans -Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity

Diana Torres‐García, M. Thierry Shema, Alexi J. C. Sarris, Shimrit David et autres

Click-triggered reactivation of caged cytokine constructs at the tumour site via a Diels–Alder–pyridazine-elimination cascade restores signalling and immune activation. This approach reduces systemic toxicity of immunocytokine therapies.

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Cover Picture: Transforming Aryl‐Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans‐Cyclooctenes (Angew. Chem. Int. Ed. 5/2025)

Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres

Bioorthogonal bond-cleavage reactions enable precise control of (bio)molecular function in biological systems. In their Research Article (e202411707), Hannes Mikula et al. report the development of “yellow” hydroxyaryl-tetrazines as bioorthogonal tools for efficient click-to-release of trans-cyclooctenes. The cover picture illustrates the transformation of …

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Titelbild: Hydroxylierte Aryl‐Tetrazine als bioorthogonale Scheren zur systematischen Spaltung von trans‐Cyclooctenen (Angew. Chem. 5/2025)

Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres

Bioorthogonal bond-cleavage reactions enable precise control of (bio)molecular function in biological systems. In their Research Article (e202411707), Hannes Mikula et al. report the development of “yellow” hydroxyaryl-tetrazines as bioorthogonal tools for efficient click-to-release of trans-cyclooctenes. The cover picture illustrates the transformation of …

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Transforming Aryl‐Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans ‐Cyclooctenes

Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres

Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, the tetrazine-triggered elimination of cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an …

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Hydroxylierte Aryl‐Tetrazine als bioorthogonale Scheren zur systematischen Spaltung von trans ‐Cyclooctenen

Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres

Abstract Bioorthogonale Bindungsspaltungsreaktionen haben sich als leistungsstarke Werkzeuge für die präzise zeitliche und räumliche Kontrolle (bio)molekularer Funktionen in biologischen Systemen etabliert. Unter diesen sticht die durch Click‐Reaktion mit Tetrazinen ausgelöste Eliminierung spaltbarer trans ‐Cyclooctene (Click‐Spaltung, engl. Click‐to‐Release) aufgrund hoher Reaktionsraten sowie ihrer …

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Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes

Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres

Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, the tetrazine-triggered elimination of cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an …

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Iontronic devices for controlled drug release with electronic precision

Marle Vleugels, Johannes Bintinger, Iwona Bernacka Wojcik, Nikolaus Poremba et autres

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Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes

Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres

Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, the tetrazine-triggered elimination of cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an …

at, us, cz (code pays fourni par la source)

Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes

Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres

Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, the tetrazine-triggered elimination of cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an …

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Post-radiolabeling thioether oxidation to enhance the bioorthogonal reactivity of 18F-tetrazines

Martin Wilkovitsch, Dennis Svatunek, Hannes Mikula, Christoph Denk

Abstract Radiolabeled 1,2,4,5-tetrazines are powerful heterocyclic agents for bioorthogonal PET imaging due to their fast cycloaddition with trans-cyclooctenes. However, fluorine-18 radiolabeling of highly reactive tetrazines is often not feasible due to limited compound stability. We demonstrate that post-radiolabeling oxidation of thioether functionalities …

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In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy

Jina Ko, Kilean Lucas, Rainer H. Köhler, Elias A. Halabi et autres

The ability to observe cells in live organisms is essential for understanding their function in complex in vivo milieus. A major challenge today has been the limited ability to perform higher multiplexing beyond four to six colors to define cell subtypes in …

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Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes

Jina Ko, Martin Wilkovitsch, Juhyun Oh, Rainer H. Köhler et autres

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