Veronika Šlachtová

NMR and HRMS data for Development of Blue-to-Near-Infrared rTCO–Caged Fluorogenic Probes for Click-to-Release Monitoring

Marek Chovanec, Veronika Šlachtová, Paul Eduardo Reyes-Gutiérrez, Simona Bellová et autres

cz (code pays fourni par la source)

NMR and HRMS data for Development of Blue-to-Near-Infrared rTCO–Caged Fluorogenic Probes for Click-to-Release Monitoring

Marek Chovanec, Veronika Šlachtová, Paul Eduardo Reyes-Gutiérrez, Simona Bellová et autres

cz (code pays fourni par la source)

Dataset related to article: "ChemCell: Bioorthogonal surface reprogramming of natural killer cells for antibody-directed cancer immunotherapy".

Oksana Tsyklauri, Simona Bellová, Pavla Duspiva, Rastislav Dzijak et autres

This dataset contains raw flow cytometry (.fcs) data and associated metadata supporting the study "ChemCell: Bioorthogonal surface reprogramming of natural killer cells for antibody-directed cancer immunotherapy". The dataset includes experiments analyzing surface modification of cells, antibody binding, antigen density, cytotoxic activity of …

cz (code pays fourni par la source)

Dataset related to article: "ChemCell: Bioorthogonal surface reprogramming of natural killer cells for antibody-directed cancer immunotherapy".

Oksana Tsyklauri, Simona Bellová, Pavla Duspiva, Rastislav Dzijak et autres

This dataset contains raw flow cytometry (.fcs) data and associated metadata supporting the study "ChemCell: Bioorthogonal surface reprogramming of natural killer cells for antibody-directed cancer immunotherapy". The dataset includes experiments analyzing surface modification of cells, antibody binding, antigen density, cytotoxic activity of …

cz (code pays fourni par la source)

ChemCell: Chemical Tethering of Large Biomolecules to Cell Surfaces through Diels-Alder Ligation

Rastislav Dzijak, Simona Bellová, Anna Kovalova, Veronika Šlachtová et autres

ABSTRACT Chemical engineering of cellular surfaces offers a powerful tool to endow cells with new properties and functions, yet methods for adding complex biomolecules to cell membranes remain underdeveloped. While technologies for targeted degradation of cell surface components are advancing, few approaches …

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Beyond traditional strain-promoted azide–alkyne cycloadditions by achieving orthogonality and rapid kinetics with fluoroalkyl azides

Matúš Tomčo, Veronika Šlachtová, Milan Vrábel, Jialu Li et autres

Strain-promoted azide–alkyne cycloaddition (SPAAC) is a cornerstone of bioorthogonal chemistry, offering metal-free and biocompatible ligation for applications ranging from bioconjugation to live-cell imaging. However, its relatively slow kinetics and limited selectivity hinder the simultaneous labelling of multiple targets. Here, we report on …

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XZYstructures and NMR files to Fluorescence Quenching Properties and Bioimaging Applications of Readily Accessible Blue to Far-Red Fluorogenic Triazinium Salts

Milan Vrábel, Veronika Šlachtová, Daniel Bím

The dataset includes data of XYZ coordinates of calculated structures and NMR data (mnova file and pdf). This dataset belongs to a publication, Fluorescence Quenching Properties and Bioimaging Applications of Readily Accessible Blue to Far-Red Fluorogenic Triazinium Salts (https://pubs.acs.org/doi/10.1021/jacs.5c17428).

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XZYstructures and NMR files to Fluorescence Quenching Properties and Bioimaging Applications of Readily Accessible Blue to Far-Red Fluorogenic Triazinium Salts

Milan Vrábel, Veronika Šlachtová, Daniel Bím

The dataset includes data of XYZ coordinates of calculated structures and NMR data (mnova file and pdf). This dataset belongs to a publication, Fluorescence Quenching Properties and Bioimaging Applications of Readily Accessible Blue to Far-Red Fluorogenic Triazinium Salts (https://pubs.acs.org/doi/10.1021/jacs.5c17428).

cz (code pays fourni par la source)

A sulfinate–azide hybrid reagent for sequential radical fluoroalkylation and click reaction

Pallavi Halkarni, Mykyta Ziabko, Veronika Šlachtová, Marek Opelka et autres

2-Azido-1,1,2,2-tetrafluoroethanesulfinate is a new radical reagent to introduce the CF 2 CF 2 N 3 moiety to a variety of (hetero)aromatics, thiols and alkenes. The adducts were clicked to alkynes, including a modified antibody.

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Fluorescence Quenching Properties and Bioimaging Applications of Readily Accessible Blue to Far-Red Fluorogenic Triazinium Salts

Veronika Šlachtová, Daniel Bím, Krisztina Németh, Eliza Barańska et autres

High Resolution Image Download MS PowerPoint Slide Fluorogenic probes, which become fluorescent only upon specific activation, enable no-wash imaging with an excellent signal-to-noise ratio. Despite significant progress in the development of such probes, challenges remain in achieving efficient quenching and substantial fluorescence …

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Haloaminocyclopropanes as Precursors of Natural Product-like Polycyclic Compounds

Veronika Šlachtová, Nicolas Casaretto, Lucie Brulíková, Yvan Six

International audience

Beyond Traditional SPAAC: Achieving Orthogonality and Rapid Kinetics with Fluoroalkyl Azides

Matúš Tomčo, Veronika Šlachtová, Milan Vrábel, Jialu Li et autres

Strain-promoted azide–alkyne cycloaddition (SPAAC) is a cornerstone of bioorthogonal chemistry, offering metal-free and biocompatible ligation for applications ranging from bioconjugation to live-cell imaging. However, its relatively slow kinetics and limited selectivity hinder the simultaneous labelling of multiple targets. Here, we report on …

cz (code pays fourni par la source)