Xiaoyue Yang

Narrative Medicine in Intermediate and Advanced Lung Cancer Patients' Quality of Life, Negative State of Mind, and Sleep Quality: A Single-Arm, Prospective Clinical Trial

Xiaoyue Yang, Song Zhou, Lin Chen, Fengjia Long et autres

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A Diketone Linchpin Strategy for On-DNA Macrocyclization and Late-Stage Diversification

Qigui Nie, Junshan Fan, Xianfu Fang, Xiaoyue Yang et autres

We report a DNA-compatible linchpin strategy for the construction and late-stage diversification of macrocyclic peptide DNA-encoded libraries (MPDELs). Treatment of DNA-conjugated linear peptides with 1,5-dichloropentane-2,4-dione (DPD) enabled highly efficient macrocyclization while introducing a versatile 1,3-diketone linchpin. Subsequent DNA-compatible late-stage diversification afforded four …

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Training status, needs, and factors associated with prior participation in phase II cardiac rehabilitation exercise prescription training among cardiopulmonary rehabilitation nurses: a cross-sectional study with an exploratory nomogram analysis

Liu Rui, Hui Ji, Xiang Zhou, Xiaoyue Yang et autres

BACKGROUND: Phase II cardiac rehabilitation is essential for patient recovery, and nurses play a central role in implementing exercise prescriptions. However, training systems for this competency remain underdeveloped in China. This study examined the training status and self-reported training needs of nurses …

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Relationship between hemodynamic forces based on CMR and major adverse cardiac events in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors

Duo Gao, Yuzhao Wang, Yanshuo Shi, Yuege Li et autres

BACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved the management of many malignancies, but immunotherapy-mediated major adverse cardiac events (MACE) should not be ignored. We aim to explore the relationship between hemodynamic forces (HDFs) of cardiovascular magnetic resonance (CMR) parameters and MACE …

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Effect of polyunsaturated fatty acids supplementation on nutritional status in patients with pancreatic cancer: a systematic review and meta-analysis

G X Liu, Chongcong Wu, Xiaoyue Yang, Z.H. Liu et autres

Background Patients with pancreatic cancer frequently experience malnutrition that is often unresponsive to conventional nutritional interventions. Objective To evaluate the impact of n-3 polyunsaturated fatty acids (PUFAs), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), supplementation on body weight (BW), lean body …

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Gut Microbiota and Probiotics in Influenza: A Narrative Review of Mechanisms and Emerging Evidence

Feihu Guan, Jie Zhang, Ye Tian, BOFAN FU et autres

The gut microbiota, often referred to as the "forgotten organ", plays an indispensable role in maintaining host physiological metabolism, immune function, and nutrient absorption. Moreover, the gut microbiome serves as a critical biological barrier against viral infections and is increasingly recognized as …

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An integrated microfluidic system for automatic and self-validated analysis of cervical extracellular vesicle markers PD-L1 and ERBB3

Yunxing Lu, Han Qin, Wen Zhang, Qiang Shi et autres

Abstract The early and precise diagnosis of gynecological malignancies, such as cervical cancer, is critical for improving patient treatments. Extracellular vesicles (EVs), such as exosomes, which carry molecular signals from their parental cells, offer a promising method for non-invasive liquid biopsy, however, …

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Spatial control of genome editing activity enables localized immunotherapy

Xiaoyue Yang, Laura Tong, Yidan Pan, Jin Huang et autres

Precise control of genome editing activity in vivo remains a major barrier to the clinical translation of CRISPR-based therapeutics, as current approaches cannot reliably restrict editing activity to target tissues 1,2,3 . Here we show that a magnetically gated baculoviral CRISPR platform …

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Selective hydrogenolysis of cellulose to 2,5-hexadione in water–tetrahydrofuran systems

Wenxiu Huang, Xiaoyue Yang, Shenghua Yuan, Xiaoyuan Liao

This study investigated the selective conversion of cellulose to 2,5-hexanedione (HXD) in a mixed deionized water/tetrahydrofuran (H 2 O/THF) solvent system using a catalytic system composed of Al 2 (SO 4 ) 3 and Pd/C.

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Sequencing Coverage Shapes Cell-Type Aging Rankings Across Single-Cell Atlases

Anmin Wang, Lauren Lai, Colin Patrick Johnson, Xiaoyue Yang et autres

Polysaccharides PFP1-1 Activate Root ”Recruitment Signals”: Beneficial Bacteria-Mediated Rhizoctonia Resistance in Cotton

Xiaoyue Yang, Chuntian Yang, Wen Hua Gao, Gulfam Yousaf et autres

Cotton damping-off caused by Rhizoctonia solani is the main limiting factor in cotton production, and it is very important to develop effective biological control methods. However, the mechanism by which biostimulants enhance crop disease resistance by recruiting beneficial rhizosphere microorganisms is unclear. …

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Comparative analysis of clinical phenotypes and genetic characteristics in MEF2C-associated neurodevelopmental disorders

Jiajun Ma, Linxue Meng, Ziyao Han, Qi Li et autres

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