Sanjiv Shrestha

Abstract 4370545: β-Hydroxybutyrate Inhibits Thoracic Aortic Aneurysm and Dissection in Mice by Suppressing Ferroptosis

Sanjiv Shrestha, Ping Song

Background: Thoracic aortic aneurysm and dissection (TAAD) is a severe vascular disease that poses life-threatening risks. Unfortunately, managing and treating TAAD remains challenging due to the absence of approved and effective pharmacological therapies. Recent studies have indicated that supplementation with the ketone …

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Targeting Gut Microbiota to Combat Vascular Aging and Cardiovascular Disease: Mechanisms and Therapeutic Potential

Jian Li, Yadong Wang, Sanjiv Shrestha, Andrew T. Gewirtz et autres

Vascular aging, characterized by arterial thickening, reduced elasticity, and endothelial dysfunction, significantly compromises vascular health and accelerates the progression of cardiovascular diseases (CVDs). Emerging research highlights the gut-vascular axis as a critical mediator of vascular health, with the gut microbiota (GM) playing …

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Abstract 4141937: Long Noncoding RNA SNRKAS as a SNRK Inhibitor Triggers Endothelium Senescence

Qiulun Lu, Sanjiv Shrestha, Ping Song

Background: Although sucrose non-fermenting 1-related kinase (SNRK) in endothelial cells (EC) has a critical role in anti-inflammation and anti-fibrosis in the kidney, whether SNRK controls EC senescence and vascular aging, and how SNRK is regulated have never been studied. Long noncoding RNAs …

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Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel

Xinping Xu, Farzana Marni, Shengjun Wu, Zhuocheng Su et autres

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Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation

Xinping Xu, Farzana Marni, Xiaoan Wu, Zhenwei Su et autres

Normal-Mode-Analysis-Guided Investigation of Crucial Intersubunit Contacts in the cAMP-Dependent Gating in HCN Channels

Farzana Marni, Shengjun Wu, Guarav Shah, Xinping Xu et autres

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