Jian Li

Gut Dysbiosis Promotes Myocardial Hypertrophy via GBP2b/GBP1 in Chronic Colitis

Yadong Wang, Jian Li, Junqing An, Vu L. Ngo et autres

BACKGROUND: Patients with inflammatory bowel disease are at increased risk of cardiovascular disease, yet the mechanisms linking chronic intestinal inflammation to cardiac dysfunction remain poorly understood. Inflammatory bowel disease is characterized by profound gut microbiota dysbiosis, which we hypothesize drives systemic immune …

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Inexact Bregman Sparse Newton Method for Efficient Optimal Transport

Jianting Pan, Jian Li, Ming Yan

Computing exact Optimal Transport (OT) distances for large-scale datasets is computationally prohibitive. While entropy-regularized alternatives offer speed, they sacrifice precision and frequently suffer from numerical instability in high-accuracy regimes. To address these limitations, we propose the Inexact Bregman Sparse Newton (IBSN) method, …

Inexact Bregman Sparse Newton Method for Efficient Optimal Transport

Jianting Pan, Jian Li, Ming Yan

Computing exact Optimal Transport (OT) distances for large-scale datasets is computationally prohibitive. While entropy-regularized alternatives offer speed, they sacrifice precision and frequently suffer from numerical instability in high-accuracy regimes. To address these limitations, we propose the Inexact Bregman Sparse Newton (IBSN) method, …

Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axis

Jian Li, Dayong Li, Fujie Zhao, Yadong Wang et autres

Endothelial cell (EC) dysfunction is a hallmark of obesity and Type 2 diabetes mellitus (T2DM), yet the mechanisms linking vascular stress to systemic metabolic diseases remain unclear. Here, we investigated the role of the mitochondrial protein FUN14 domain-containing 1 (FUNDC1) in EC …

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A study on the value of the relationship between newly occurring microinfarctions after stent-assisted treatment for unruptured intracranial aneurysms and systemic inflammatory immune indices

Yifan Lv, Tao Zhang, Chunxia Li, G. Han et autres

Background: A paucity of studies has been conducted on the relationship between new microinfarctions following stent-assisted treatment for unruptured intracranial aneurysms (UIA) and systemic inflammatory indices (SII) derived from complete blood counts (CBC) and clinical outcomes. The objective of this study was …

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Angiogenesis and Related Disorders: Emerging Insights and Future Directions

Hongmin Yao, Jian Li

Angiogenesis, the formation of new blood vessels from preexisting vasculature, is fundamental to both physiological homeostasis and pathological remodeling [...].

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Cost-Utility Analysis of Accelerated and Standard Strategies for Renal Replacement Therapy Initiation

Jeff Round, İlke Akpinar, Charles Yan, Natasha Patel et autres

Importance: Little is known about the long-term costs and outcomes related to strategies for timing of initiation of kidney replacement therapy (KRT) in critically ill patients with severe acute kidney injury (AKI). Objective: To estimate the cost-utility and cost-effectiveness of accelerated KRT …

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Association of estimated pulse wave velocity with cardiovascular disease outcomes and all-cause death—a systematic review and meta-analysis

Jian Li, Fei Gao, Fang Cao, Shan Lv et autres

Background: The estimated pulse wave velocity (ePWV), derived from age and mean blood pressure (MBP) in accordance with the Reference Values of Arterial Stiffness Collaboration, has emerged as a novel alternative indicator for assessing arterial stiffness. This systematic review and meta-analysis aims …

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Targeting Gut Microbiota to Combat Vascular Aging and Cardiovascular Disease: Mechanisms and Therapeutic Potential

Jian Li, Yadong Wang, Sanjiv Shrestha, Andrew T. Gewirtz et autres

Vascular aging, characterized by arterial thickening, reduced elasticity, and endothelial dysfunction, significantly compromises vascular health and accelerates the progression of cardiovascular diseases (CVDs). Emerging research highlights the gut-vascular axis as a critical mediator of vascular health, with the gut microbiota (GM) playing …

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Proteomics and metabolomics studies in pigmented villonodular synovitis uncover the regulation of monocyte differentiation by the ADGRE5-NF-κB pathway

Minghao Ge, Runze Yang, Baojun Xu, Lei Fan et autres

BACKGROUND: Pigmented villonodular synovitis (PVNS), or tenosynovial giant cell tumor (TGCT), is a locally aggressive soft tissue tumor primarily affecting the synovium of joints, particularly the knee. In PVNS, the synovial tissue thickens and becomes aggressive, leading to joint destruction, a process …

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Determination of 79 pesticide residues in fruits and vegetables by QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry

Zhao Le, Xianjun Liu, Hao Zhang, Jian Li et autres

Pesticide residues in fruits and vegetables are becoming a serious issue. These residues can affect the quality of agricultural products and people’s health. Therefore， it has become crucial to effectively monitor and control pesticide residues in the food safety field. In this …

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Pulmonary vein isolation with or without empiric superior vena cava isolation in patients undergoing ablation for paroxysmal atrial fibrillation: the randomized ESVCI-AF trial

Wenzhi Shen, Yuzhen Zhang, Weichun Qian, Cheng Wang et autres

AIMS: The superior vena cava (SVC) has been implicated as a non-pulmonary vein trigger in the initiation and maintenance of atrial fibrillation (AF). However, the incremental benefit of empiric SVC isolation (SVCI) in addition to pulmonary vein isolation (PVI) for paroxysmal AF …

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