Xiaoan Wu

Steric Gating Dictates Selective Activation of BIRC6 by UBA6 Over UBA1

Zhengjia Tong, Rujing Yuan, Xiaoan Wu, Hongyi Cai et autres

Abstract The giant E2–E3 chimera BIRC6 is specifically activated by the ubiquitin-activating enzyme UBA6, but not by UBA1. This specificity allows BIRC6 to ubiquitinate downstream substrates (e.g., caspases) and thereby regulate apoptosis. However, the molecular mechanism that underlies UBA6mediated specific activation of …

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RR-SMO: A novel optimization algorithm for enhancing route efficiency in outdoor sports equipment

Xinxin Zhou, Xiaoan Wu, Mingwei Wang

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CLIP-BCA-Gated: A Dynamic Multimodal Framework for Real-Time Humanitarian Crisis Classification with Bi-Cross-Attention and Adaptive Gating

Shanshan Li, Qingjie Liu, Zhian Pan, Xiaoan Wu

During humanitarian crises, social media generates over 30 million multimodal tweets daily, but 20% textual noise, 40% cross-modal misalignment, and severe class imbalance (4.1% rare classes) hinder effective classification. This study presents CLIP-BCA-Gated, a dynamic multimodal framework that integrates bidirectional cross-attention (Bi-Cross-Attention) …

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Abstract 2869: DXC014, a novel bispecific ADC targeting B7-H3 and PSMA, demonstrates favorable antitumor efficacy and safety profiles in preclinical evaluations

Huihui� Guo, Zhicang Ye, Yuanyuan Huang, Weibin Li et autres

Abstract B7-H3 (also known as CD276), a member of the B7 ligand family, is overexpressed on differentiated malignant cells and cancer-initiating cells, with limited heterogeneity, and high frequency (60% of 25,000 tumor samples), such as the cells of prostate cancer, non-small cell …

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Bioinformatics Analysis Reveals SRPX as a Potential Therapeutic Target in Gastric Cancer

Guoqin Qiu, Xiaoan Wu, Wenda Wu, Shuitu Feng

Gastric cancer is the fourth most common cancer in the world in terms of cancer mortality, threatening people's health and safety. Advanced gastric cancer cannot be eradicated by surgery, and the effect of traditional treatment is not satisfactory. Targeted therapy and immunotherapy …

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BPS2025 - Pufa stabilizes a conductive state of the selectivity filter in IKs channels

Alessia Golluscio, Jodene Eldstrom, Jessica J. Jowais, Marta E. Perez-Rodriguez et autres

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BPS2025 - Biophysical properties of BK channelopathies in heterozygous conditions

Xiaoan Wu, Yanyan Geng, Alice Butler, Lawrence Salkoff et autres

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BPS2025 - The effects of long QT syndrome-associated mutation R231C on the cardiac IKs channel

Yahnell Judah, Xiaoan Wu, Marta Elena Perez, Peter H. Larsson

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BPS2025 - The effects of long QT syndrome associated mutation R231C on the cardiac IKs channel

Yahnell Judah, Xiaoan Wu, Marta Elena Perez, Peter H. Larsson

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Multi-Objective Optimization Algorithm for Vnf Migration with Priority Awareness in Dynamic Networks

Yu Luo, Zhaogang Shu, Shuwu Chen Chen, Qiang Tu et autres

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A Review of Coral Calcium Hydride in the Treatment of Athletic Oxidative Stress Injuries

Meiling Huang, Zhengqing Ma, Xiaoan Wu, Yanzhen Wang et autres

Coral calcium hydride is a novel and highly efficient solid-state molecular hydrogen carrier with biological functions such as antioxidant, lowering inflammation level, reducing apoptosis and improving mitochondrial function, which can resist oxidative stress through effective supplementation of coral calcium hydride. This review …

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Author response: PUFA stabilizes a conductive state of the selectivity filter in IKs channels

Alessia Golluscio, Jodene Eldstrom, Jessica J. Jowais, Marta Elena Perez et autres

Travelling through the heart are waves of electrical activity that cause muscle cells to contract and pump blood around the body. The waves are generated by charged ions which flow via tiny channels in and out of the muscle cells. This electrical …

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