Accès ouvert
2026
article
OpenAlex
Ian García‐Aguirre, Jesús Alejandro Reyes-Martínez, Juan Unzueta, Francisco Guevara‐Namorado et autres
In Hutchinson-Gilford progeria syndrome (HGPS), dysfunctional autophagy results in the accumulation of progerin, a lamin A mutant variant that alters a plethora of processes, inducing senescence and driving premature aging. Therefore, the elimination of progerin through autophagy restoration emerges as a therapeutic …
mx, us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Christopher D. Lu, Ajay Kumar Jain, Ángel Baldán, Rajeev Aurora et autres
Background: The postmenopausal state increases atherosclerosis in women, yet the molecular and cellular mechanisms remain largely elusive. Smooth muscle cells (SMC) and their phenotypic modulation play a crucial role in atherosclerosis. How estrogen depletion alters SMC phenotype during atherosclerosis remains to be …
es, us
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Jeannine M. Basta, Lynn W. Robbins, Lisa Stout, Michelle Brennan et autres
ABSTRACT Low nephron endowment at birth is a risk factor for chronic kidney disease. The prevalence of this condition is increasing due to higher survival rates of preterm infants and children with multi- organ birth defect syndromes that affect the kidney and …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Susana Gonzalo, Rafael Cançado de Faria, Elena V. Shashkova, Colin A. Flaveny et autres
Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disease caused by the mutant lamin-A protein "progerin," features robust sterile inflammation/interferon (IFN)-like response.Targeting inflammation delays cellular and organismal HGPS phenotypes.However, specific mechanisms driving the sterile inflammation/IFN-like response and how this response causes tissue …
es, us, be
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela King-Wah Cheng et autres
Background: Removal of circulating plasma low-density lipoprotein cholesterol (LDL-C) by the liver relies on efficient endocytosis and intracellular vesicle trafficking. Increasing the availability of hepatic LDL receptors (LDLRs) remains a major clinical target for reducing LDL-C levels. Here, we describe a novel …
us, gb, es
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela King-Wah Cheng et autres
Abstract Increasing the availability of hepatic low-density lipoprotein receptors (LDLR) remains a major clinical target for reducing circulating plasma LDL cholesterol (LDL-C) levels. Here, we identify the molecular mechanism underlying genome-wide significant associations in the GOLIATH locus with plasma LDL-C levels. We …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Junseo Oh, Scot J. Matkovich, Amy Elizabeth Riek, Sharell M. Bindom et autres
Abstract Myeloid cells are known mediators of hypertension, but their role in initiating renin-induced hypertension has not been studied. Vitamin D deficiency causes pro-inflammatory macrophage infiltration in metabolic tissues and is linked to renin-mediated hypertension. We tested the hypothesis that impaired vitamin …
us, be
(code pays fourni par la source)
2020
conference-abstract
OpenAlex
Bethan L. Clifford, Kelsey E. Jarrett, Pauline Morand, Joan Cheng et autres
Rationale and Objective: Low-density lipoprotein cholesterol (LDL-C) levels are the strongest predictor of cardiovascular disease (CVD) and morbidity in the United States. Current therapeutic strat...
Accès ouvert
2020
article
OpenAlex
Anna Cline-Smith, Ariel Axelbaum, Elena V. Shashkova, Mousumi Chakraborty et autres
ABSTRACT The loss of estrogen (E2) initiates a rapid phase of bone loss leading to osteoporosis in one-half of postmenopausal women, but the mechanism is not fully understood. Here, we show for the first time how loss of E2 activates low-grade inflammation …
us
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Nathan L. Price, Verónica Miguel, Wen Jiang Ding, Abhishek K. Singh et autres
Previous work has reported the important links between cellular bioenergetics and the development of chronic kidney disease, highlighting the potential for targeting metabolic functions to regulate disease progression. More recently, it has been shown that alterations in fatty acid oxidation (FAO) can …
us, es, br, bd
(code pays fourni par la source)
Accès ouvert
2019
preprint
OpenAlex
Tyler J. Marquart, Ryan M. Allen, Mary R. Chen, Gerald W. Dorn et autres
Statins are the most common pharmacologic intervention in hypercholesterolemic patients, and their use is recognized as a key medical advance leading to a 50% decrease in deaths from heart attack or stroke over the past 30 years. The atheroprotective outcomes of statins …
es, us, be
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Ray Kreienkamp, Cyrielle Billon, Gonzalo Bedia‐Diaz, Carolyn J. Albert et autres
Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients. Barriers to developing effective therapies include the …
us
(code pays fourni par la source)