Anna Cline-Smith

Estrogen loss activates memory T-cells to compromise bone integrity through distinct cortical compartments in mice

Di Wu, Anna Cline-Smith, Daniel Goering, Rajeev Aurora

Fragility fractures are a significant cause of morbidity and mortality in postmenopausal women. Menopause leads to a drastic decline in bone mass and quality with over half of women sustaining fragility fractures without reaching the osteoporotic threshold (T-score < -2.5), underscoring the …

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LAVR-289, a broad-spectrum antiviral, protects immunosuppressed Syrian hamsters against lethal adenovirus challenge

Ann E. Tollefson, Anna Cline-Smith, Vincent Roy, Luigi André Agrofoglio et autres

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LAVR-289, an Orally Bioavailable Inhibitor of Adenovirus Replication In Vitro and In Vivo

Charlotte Quentin-Froignant, Ann E. Tollefson, Anna Cline-Smith, Sandrine Kappler‐Gratias et autres

Adenoviruses are responsible for a range of pathologies, including respiratory infections in children. Although most adenovirus infections are self-resolving, they can cause serious illness, particularly in immunocompromised individuals. There is currently no approved treatment for adenovirus infections. Here, we report on the …

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LAVR-289, a New Orally Bioavailable Inhibitor of Adenovirus Replication in vitro and in vivo

Charlotte Quentin-Froignant, Ann E. Tollefson, Anna Cline-Smith, Sandrine Kappler‐Gratias et autres

Abstract Adenoviruses are responsible for a range of pathologies, including respiratory infections in children, accounting for 5-10% of such cases. Although most adenovirus infections are self-resolving, they can cause serious illness, particularly in immunocompromised individuals. There is currently no approved treatment for …

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Lavr-289, a Broad-Spectrum Antiviral, Protects Immunosuppressed Syrian Hamsters Against Lethal Adenovirus Challenge

Ann E. Tollefson, Anna Cline-Smith, Vincent Roy, Luigi André Agrofoglio et autres

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Synthesis of USC-093 and comparison with its promoiety enantiomer USC-093D against adenovirus in vitro and in a Syrian hamster model

Samantha B. Riemann, Jinglei Lyu, Yang Bi, Nicholas A. Lentini et autres

ABSTRACT Adenovirus infections of immunocompromised humans are a significant source of morbidity and mortality. At present, no drug has been approved by FDA for the treatment of adenovirus infections. A current treatment of such infections is off-label use of an antiviral acyclic …

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Memory T-Cells Contribute to Calcium Release from Bones during Lactation in Mice

Di Wu, Anna Cline-Smith, Brady Chrisler, Brittani Lubeck et autres

Objective: Milk production during lactation places a high demand for calcium that is fulfilled both from maternal bone resorption and diet. While it is known that mammary gland-derived PTHrP drives bone resorption during lactation, the impact of postpartum estrogen loss on bone …

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Longitudinal Monitoring of the Effects of Anti-Adenoviral Treatment Regimens in a Permissive In Vivo Model

Ann E. Tollefson, Anna Cline-Smith, Jacqueline F. Spencer, Baoling Ying et autres

Adenovirus infections of immunocompromised patients can cause life-threatening disseminated disease. While there are presently no drugs specifically approved to treat these infections, there are several compounds that showed efficacy against adenovirus in preclinical studies. For any such compound, low toxicity is an …

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NPP-669, a prodrug of cidofovir, is highly efficacious against human adenovirus infection in the permissive Syrian hamster model

Ann E. Tollefson, Anna Cline-Smith, Jacqueline F. Spencer, Dawn M. Reyna et autres

ABSTRACT Human adenoviruses can cause serious, disseminated infections in immunocompromised patients. For pediatric allogeneic stem cell transplant patients, the case fatality rate can reach 80%. Still, there is no available antiviral drug that is specifically approved by the Food and Drug Administration …

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T-Cell Mediated Inflammation in Postmenopausal Osteoporosis

Di Wu, Anna Cline-Smith, Elena V. Shashkova, Ajit Perla et autres

Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone resorption that leads to low bone mass, compromised microarchitecture and structural deterioration that increases the …

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Osteoporosis: A Multifactorial Disease

Di Wu, Anna Cline-Smith, Elena V. Shashkova, Rajeev Aurora

A great achievement of modern medicine is the increased lifespan of the human population. Unfortunately, the comorbidities of aging have created a large economic and health burden on society. Osteoporosis is the most prevalent age-related disease. It is characterized by uncoupled bone …

Ovariectomy Activates Chronic Low-Grade Inflammation Mediated by Memory T Cells, Which Promotes Osteoporosis in Mice

Anna Cline-Smith, Ariel Axelbaum, Elena V. Shashkova, Mousumi Chakraborty et autres

ABSTRACT The loss of estrogen (E2) initiates a rapid phase of bone loss leading to osteoporosis in one-half of postmenopausal women, but the mechanism is not fully understood. Here, we show for the first time how loss of E2 activates low-grade inflammation …

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