Alberto Mercatanti

Correction: The landscape of BRAF transcript and protein variants in human cancer

Andrea Marranci, Zhijie Jiang, Marianna Vitiello, Elena Guzzolino et autres

it, us (code pays fourni par la source)

Changes in adiponectin system after ventricular assist device in pediatric heart failure

Rosetta Ragusa, Arianna Di Molfetta, Alberto Mercatanti, Letizia Pitto et autres

Background: Ventricular assist device (VAD) implant represents a therapeutic option for pediatric patients with end-stage heart failure (HF). Heart unloading by VAD can modify several molecular pathways underlying cardiac function in HF. Among them, the potential role of microRNA (miRNAs) in response …

it (code pays fourni par la source)

Secreted miR-210-3p, miR-183-5p and miR-96-5p reduce sensitivity to docetaxel in prostate cancer cells

Maristella Canovai, Monica Evangelista, Alberto Mercatanti, Romina D’Aurizio et autres

Abstract Docetaxel (DCT) resistance is one of the main factors responsible for treatment failure in metastatic prostate cancer (PCa). Although several mechanisms of DCT resistance have been elucidated, the issue is still far from comprehensive. In this work we show that miR-96-5p, …

it (code pays fourni par la source)

A Network of MicroRNAs and mRNAs Involved in Melanosome Maturation and Trafficking Defines the Lower Response of Pigmentable Melanoma Cells to Targeted Therapy

Marianna Vitiello, Alberto Mercatanti, Maurizio Podda, Caterina Baldanzi et autres

BACKGROUND: The ability to increase their degree of pigmentation is an adaptive response that confers pigmentable melanoma cells higher resistance to BRAF inhibitors (BRAFi) compared to non-pigmentable melanoma cells. METHODS: Here, we compared the miRNome and the transcriptome profile of pigmentable 501Mel …

it (code pays fourni par la source)

Validation and Data-Integration of Yeast-Based Assays for Functional Classification of BRCA1 Missense Variants

Francesca Bellè, Alberto Mercatanti, Samuele Lodovichi, Caterina Congregati et autres

Germline mutations in the BRCA1 gene have been reported to increase the lifetime risk of developing breast and/or ovarian cancer (BOC). By new sequencing technologies, numerous variants of uncertain significance (VUS) are identified. It is mandatory to develop new tools to evaluate …

it (code pays fourni par la source)

RAD52 influences the effect of BRCA1/2 missense variants on homologous recombination and gene reversion in Saccharomyces cerevisiae

Samuele Lodovichi, Francesca Bellè, Alberto Mercatanti, Laura Spugnesi et autres

The breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, are key players in the homologous recombination (HR) repair pathway and act as tumor suppressors by maintaining genome stability. The yeast Saccharomyces cerevisiae has no BRCA1/2 homolog; however, a number of HR …

it (code pays fourni par la source)

Epigenetic Regulation of Cardiac Troponin Genes in Pediatric Patients with Heart Failure Supported by Ventricular Assist Device

Rosetta Ragusa, Arianna Di Molfetta, Serena Del Turco, Manuela Cabiati et autres

Ventricular Assist Device (VAD) therapy is considered as a part of standard care for end-stage Heart Failure (HF) children unresponsive to medical management, but the potential role of miRNAs in response to VAD therapy on molecular pathways underlying LV remodeling and cardiac …

it (code pays fourni par la source)

Cardiac miRNAs were involved in the regulation of pathophysiological mechanisms underlying HF in pediatric patients after ventricular assist device implantation

Rosetta Ragusa, Arianna Di Molfetta, Salvatore Turco, Giuseppina Basta et autres

Abstract Background VAD use in heart failure (HF) children have undergone rapid progress in the last three decades through pump technological innovation and improvement of perioperative care. Studies in HF adults showed that VAD put native heart at rest and lead to …

it (code pays fourni par la source)

A eutherian-specific microRNA controls the translation of Satb2 in a model of cortical differentiation

Manuella Martins, Silvia Giulia Galfrè, Marco Terrigno, Luca Pandolfini et autres

Cerebral cortical development is controlled by key transcription factors that specify the neuronal identities in the different layers. The mechanisms controlling their expression in distinct cells are only partially known. We investigated the expression and stability of Tbr1, Bcl11b, Fezf2, Satb2, and …

it, es (code pays fourni par la source)

An Eutherian-Specific microRNA Controls the Translation of Satb2 in a Model of Cortical Differentiation

Manuella Martins, Silvia Giulia Galfrè, Marco Terrigno, Luca Pandolfini et autres

ABSTRACT Cerebral cortical development is controlled by key transcription factors that specify the neuronal identities in the different cortical layers. These transcription factors are crucial for the identity of the different neurons, but the mechanisms controlling their expression in distinct cells are …

it, es (code pays fourni par la source)

T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk

Francesca Forini, Giuseppina Nicolini, Claudia Kusmic, Romina D’Aurizio et autres

The LncRNA my-heart (Mhrt) and the chromatin remodeler Brg1 inhibit each other to respectively prevent or favor the maladaptive α-myosin-heavy-chain (Myh6) to β-myosin-heavy-chain (Myh7) switch, so their balance crucially guides the outcome of cardiac remodeling under stress conditions. Even though triiodothyronine (T3) …

it (code pays fourni par la source)

The miR-28-5p Targetome Discovery Identified SREBF2 as One of the Mediators of the miR-28-5p Tumor Suppressor Activity in Prostate Cancer Cells

Sofia Fazio, Gabriele Berti, Francesco Russo, Monica Evangelista et autres

miR-28-5p is downregulated in some tumor tissues in which it has been demonstrated to have tumor suppressor (TS) activity. Here, we demonstrate that miR-28-5p acts as a TS in prostate cancer (PCa) cells affecting cell proliferation/survival, as well as migration and invasion. …

fr, it, dk (code pays fourni par la source)