Jing Lu

Spermidine, a chondrocyte apoptotic metabolite, delays osteoarthritis by regulating macrophage M2c polarization

Jing Lu, Hongbiao Sun, Fan Zhang, Guangnan Wang et autres

Chondrocyte apoptosis and synovial macrophage polarization represent two key pathological hallmarks of osteoarthritis (OA), but the interplay between them remains largely unknown. This study aimed to investigate the roles and mechanisms of the chondrocyte apoptotic secretome in mediating macrophage polarization during the …

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Integrated bioinformatic evaluation unveils a cellular senescence gene signature as a poor prognostic factor in hepatocellular carcinoma

Shaoyang Lu, Junjie Ma, X Wang, L Zhang et autres

Cellular senescence (CS) plays a crucial role in various diseases, but its role in hepatocellular carcinoma (HCC) remains unclear. CS-related genes were clustered to identify subtypes. A risk score was constructed and validated in three independent cohorts. Associations with clinical characteristics, tumor …

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Reliability, validity, and usability of an 18-item immersive virtual reality action research arm test: a validation study in stroke survivors

Zhipeng Pan, H L Wang, Yue Sun, Zhen Wei et autres

Background Stroke is a leading cause of adult disability, with upper extremity hemiparesis affecting approximately 80% of survivors. While the Action Research Arm Test (ARAT) is the reference standard for assessing motor function, its clinical use is hindered by being resource-intensive and …

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Gut Regulated Associations of Neuronal Signalling in High Blood Pressure (GRAINS-BP): a double-blinded randomised crossover placebo-controlled trial

Malindi Welathanthree, Matthew Snelson, Donggyu Rim, Brendan McCarthy et autres

Hypertension affects 1 in 3 Australian adults and is a major contributor to stroke and myocardial infarction. Despite the availability of various medications, over 50% of patients struggle to control their blood pressure (BP) due to nonadherence, difficulty finding the right treatment, …

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The role of macrophages in radiation-induced lung injury: from pathological mechanisms to therapeutic targets

Xiaochi Ma, Jing Lu, Tao Zhong, Xin Wang et autres

Radiation-induced lung injury (RILI) is a major dose-limiting toxicity of chest radiotherapy (RT), and its occurrence and development are closely related to the complex role of macrophages. RT significantly modulates the recruitment and functional status of macrophages. In the early stage, macrophages …

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Thermal Therapies in The Multidisciplinary Management of Peritoneal Metastases

L Chen, J Gao, Xinpei Luo, Jing Lu et autres

Background: Peritoneal metastases arise from biologically distinct tumors and require treatment to be matched to disease distribution. Radiofrequency ablation, microwave ablation, and high-intensity focused ultrasound are focal procedures, whereas cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is directed at the peritoneal cavity. Methods: …

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The evolving landscape of Staphylococcus aureus immune evasion: a data-driven atlas over two decades

Yize Fan, S Wang, Xingyu Zhu, Xiaotong Zhang et autres

Background: ) has emerged as a significant global public health threat, owing to its complex immune evasion strategies. Despite growing research output in this field, a comprehensive, data-driven bibliometric analysis delineating its global landscape, research hotspots, and translational gaps remains lacking. Methods: …

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The LCE3D/TGF-β1 Axis in atopic dermatitis: Expression profiling, clinical significance, and mechanistic insights into epithelial-immune crosstalk

Q W Li, Wanyan Xiang, Jing Lu, Zheng W et autres

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Efficacy and safety of upadacitinib in treating immune drift: a single-center, prospective study in China

Wanyan Xiang, Jing Lu, Siqi Zhang, Zheng W et autres

Introduction With the widespread use of biologic agents in dermatology, immune drift has emerged as a growing clinical challenge. Although several case reports suggest the therapeutic potential of JAK inhibitors, clinical evidence for upadacitinib—a highly selective JAK1 inhibitor—remains limited. Methods A prospective …

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High-sensitive glycomics using seGRAP-mass spectrometry uncovers a conserved N-glycome in single human oocytes

Nafisa Tursumamat, Qiannan Liu, Jing Lu, Shuhong Guo et autres

High-sensitivity glycomic analysis is essential for advancing both basic and translational biomedical research, yet remains methodologically challenging for limited-quantity samples, primarily due to complex workflows and reliance on specialized instrumentation. Here, we introduce solution-enhanced glycan reduction and permethylation (seGRAP), a streamlined, accessible, …

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Physics-Guided Learning for Tendon State Estimation of Cable-Driven Hyper-Redundant Robots

Jiaxun He, Jing Lu, Qing-Hao Zhang, Zhenpu Zhu et autres

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High-frequency irreversible electroporation versus transurethral resection of the prostate for benign prostatic hyperplasia (GIANT): a single-centre, randomised, double-blind, phase 3, non-inferiority trial

Bi-Ming He, Rong-Bing Li, Dong-Yang Li, Lc Huang et autres

Background: Transurethral resection of the prostate (TURP) is the gold standard for treating benign prostatic hyperplasia (BPH) but frequently causes retrograde ejaculation and bleeding. High-frequency irreversible electroporation (H-FIRE) is a non-thermal ablation technique offering tissue selectivity. We aimed to compare the efficacy …

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