The role of macrophages in radiation-induced lung injury: from pathological mechanisms to therapeutic targets
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Radiation-induced lung injury (RILI) is a major dose-limiting toxicity of chest radiotherapy (RT), and its occurrence and development are closely related to the complex role of macrophages. RT significantly modulates the recruitment and functional status of macrophages. In the early stage, macrophages predominantly exhibit a pro-inflammatory M1 phenotype, releasing a large amount of inflammatory factors and exacerbating lung tissue damage. In the late stage, they shift to a pro-fibrotic M2 phenotype, promoting fibroblast activation, extracellular matrix accumulation, and epithelial-mesenchymal transition, thereby facilitating the progression of pulmonary fibrosis. In addition, the metabolic reprogramming induced by RT significantly affects the function of macrophages, manifested by imbalances in glucose, lipid, and amino acid metabolism and mitochondrial dysfunction, further reinforcing phenotypic polarization and functional heterogeneity. This complexity offers diversified strategies for the treatment of RILI by targeting macrophages, including phenotypic regulation, metabolic intervention, delivery systems and cell engineering development, and combination therapy, demonstrating new potential for mitigating RILI. However, the widespread use of immune checkpoint inhibitors has exacerbated the difficulty in preventing and treating RILI, necessitating urgent exploration of effective and safe intervention measures.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The role of macrophages in radiation-induced lung injury: from pathological mechanisms to therapeutic targets
- Date Crossref
- 22/07/2026
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Qilu Hospital of Shandong University Department of Pulmonary and Critical Care Medicine pays non établi dans la noticeÉtablissement de santé
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Shandong Provincial Hospital Department of Critical Care Medicine pays non établi dans la noticeÉtablissement de santé
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Shandong First Medical University Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
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Jining Medical University pays non établi dans la noticeUniversité ou école supérieure
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Xinjiang Medical University Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
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Tumor Hospital of Xinjiang Medical University pays non établi dans la noticeÉtablissement de santé
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College of Basic Medicine Institute of Immunology and Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Pulmonary and Critical Care Medicine — Qilu Hospital of Shandong University, Department of Critical Care Medicine — Shandong Provincial Hospital et Department of Radiation Oncology — Shandong First Medical University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.