Lobna Shalaby

Gram-negative blood-stream infections and emerging antimicrobial resistance in children with acute myeloid leukemia during induction chemotherapy at Children’s Cancer Hospital Egypt 57357

Grace Mbatia, Reham Abdelaziz Khedr, Leslie Lehmann, Mervat El Anany et autres

Background: In children receiving therapy for acute myeloid leukemia (AML), gram-negative bacteremia is associated with significant morbidity and mortality, especially in the presence of multi-drug resistant [MDR] organisms. objectives: The purpose of this study was to determine the prevalence and antibiotic susceptibility …

pk, my, Égypte, us (code pays fourni par la source)

Limits of rapid diagnostics: genomic and structural insights into OXA-48–like mediated carbapenem resistance in Escherichia coli

Aya A. Diab, Deena Jalal, Youssef M. Fadel, Omar Khalid Samir et autres

Carbapenem-resistant Escherichia coli (CREC) represent a major clinical threat because of limited treatment options and frequent multidrug resistance. While rapid molecular diagnostics improve treatment outcomes, the detection of carbapenemase genes, such as bla OXA-48 -like, does not always correspond to phenotypic resistance, …

Égypte, in (code pays fourni par la source)

Anterior vertical relationship: validation of an artificial intelligence model vs. digitally assisted human observers

Nevin Abdelmagid, Wael M. Talaat, Ahmed Kaboudan, Aasem Hamed et autres

ae, Égypte, de (code pays fourni par la source)

Improving voriconazole therapeutic drug monitoring-guided dosing through a clinical decision support system: enhancing antifungal stewardship

Marwa M. Ibrahim, Amr Kashef, Amr Elnashar, Eslam Shafiq et autres

Voriconazole (VCZ) is a first-line antifungal agent for treating invasive fungal infections. However, due to its narrow therapeutic index and high pharmacokinetic variability, standard dosing can be subtherapeutic or toxic. Therapeutic Drug Monitoring (TDM) is recommended to optimize VCZ therapy. To enhance …

Égypte, in (code pays fourni par la source)

Preemptive Versus Empirical Antifungal Therapy for High‐Risk, Febrile, Neutropenic Solid Tumor Patients in an LMIC Setting

Omnia Al‐Qadi, Lobna Shalaby, Mervat El Anany, Iman Zaky et autres

BACKGROUND: Preemptive antifungal therapy in neutropenic fever offers a rational alternative to the empiric strategy, potentially reducing drug toxicity, resistance, and treatment-related costs. However, its implementation in the Middle East and North Africa (MENA) region remains insufficiently addressed. METHODS: We prospectively observed …

Égypte, us (code pays fourni par la source)

Dual Transmission Dynamics of Carbapenem Resistance in Pediatric Oncology: Plasmid-Mediated and Clonal Spread of blaNDM-5 Enterobacterales

Deena Jalal, Maryam Lotfi, Ghada A. Ziad, Sally Mahfouz et autres

INTRODUCTION: Carbapenem-resistant Enterobacterales (CRE) pose a major threat to immunocompromised pediatric oncology patients. However, the routes of resistance spread in this vulnerable population remain poorly understood, despite their importance for guiding infection control. METHODS: We analyzed 189 CRE bloodstream isolates (106 Escherichia …

Égypte (code pays fourni par la source)

Evaluating the impact of infectious disease pharmacy services on voriconazole dose individualization in pediatric oncology

Mohamed Azab, Dalia Makhlouf, Omneya Hassanain, Lobna Shalaby et autres

Background The application of personalized medication management for Voriconazole(VCZ), such as therapeutic drug monitoring (TDM), is the gold standard for attaining therapeutic goals in invasive fungal infections. Infectious disease (ID) pharmacists are the best for ensuring the recommendations are properly implemented.Aim To …

Égypte, in (code pays fourni par la source)

Exploring the effect of femtosecond laser surface treatment on the bond strength of zirconia to metal brackets: an in vitro study

Lobna Shalaby, Hatem Saifeldin, Fatma Abdel Samad, Tarek A. Mohamed et autres

OBJECTIVE: To investigate the effect of zirconia (Zr) surface treatment with different femtosecond laser (FS) wavelengths on the shear bond strength (SBS) of metal brackets to multilayer zirconia. METHODS: ) was applied to the first group, while the other three groups were …

Égypte (code pays fourni par la source)

Tailoring pediatric vancomycin doses: achieving therapeutic levels and minimizing toxicity in oncology patients

Nadeen Hossam, Dalia Makhlouf, Ahmed Elzeiny, Akram Elzeiny et autres

Background Vancomycin is a widely used nephrotoxic drug in pediatric oncology. Our aim was to assess the initial vancomycin dosing protocols required for achieving the target therapeutic concentrations of vancomycin between 10 and 20 mcg/ml.Methods We analyzed 4134 vancomycin trough levels from …

Égypte (code pays fourni par la source)

Anterior vertical relationship: Validation of an Artificial Intelligence Model vs. Digitally assisted Human Observers

Nevin Abdelmagid, Wael M. Talaat, Ahmed Kaboudan, Sameh Talaat et autres

ae, Égypte (code pays fourni par la source)

Rapid Identification of Carbapenemase Genes Directly from Blood Culture Samples

Ghada A. Ziad, Deena Jalal, Mohamed Hashem, Ahmed A. Sayed et autres

Background/Objectives: The rapid identification of carbapenemase genes directly from positive blood culture (BC) samples shortens the time needed to initiate optimal antimicrobial therapy for Carbapenemase-Producing Enterobacterales (CPE) infections. Several commercial automated PCR systems are available for detecting CPE resistance genes but are …

Égypte (code pays fourni par la source)

Changes in Gut Microbial Diversity and Correlation with Clinical Outcome in Children with Acute Myeloid Leukemia Receiving Induction Chemotherapy

Mohamad Adel, Reham Abdelaziz Khedr, Ahmed A. Sayed, Lobna Shalaby et autres

Background: The gut microbiome affects human health, and patients with cancer are no exception. In those patients, intensive chemotherapy impairs gut barrier integrity, causing dysbiosis, bacterial translocation, and higher infection risk. Objectives: This prospective study, conducted at Children’s Cancer Hospital in Egypt, …

Égypte, us (code pays fourni par la source)