Elaheh Safari

Exploring the Therapeutic Potential of Fluorinated CXCR4 Inhibitor A1: Insights from Breast Cancer In Vitro Investigations

Ali Rahimi, Hossein Khorramdelazad, Ali Darehkordi, Gholamhossein Hassanshahi et autres

The impacts of the CXC motif chemokine 12 (CXCL12)/ C-X-C chemokine receptor type 4 (CXCR4) axis on the infiltration of anti-tumor and pro-tumor immune cells in the tumor microenvironment (TME) of breast cancer (BCa) have been noted in previous studies. Accordingly, regulating …

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Prevalence of somatic symptom disorder in Syrian patients with breast cancer: A cross-sectional study

Jamal Alshorman, Maria Karaminasian, Somayeh Sadeghi, Elaheh Safari et autres

Breast cancer is a common cancer among women in Syria, characterized by lower incidence rates compared to those in Western countries but higher mortality. This study aims to determine the prevalence of somatic symptom disorder (SSD) among breast cancer patients in Syria …

A Case Report of Rosai-Dorfman Disease in a 9-Year-Old Girl with Left Tibia Involvement: Insights into Etiology, Clinical Presentation, and Treatment Advances

Khan Akhtar Ali, Xin Bao, Mi Li, Elaheh Safari et autres

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Evaluation of CD73 , PD-1 , circHIPK3 , and circNRIP1 expression in the peripheral blood of patients with colorectal cancer

Zahra Shafaghat, Ali Arash Anoushirvani, Mehdi Nikkhah, Fatemeh Rahbari solute et autres

INTRODUCTION: Colorectal cancer (CRC) is known to have an association with circular RNAs (circRNAs) and immune checkpoint factors. This study sought to examine the expression levels of hsa_circ_0000284 and hsa_circ_0004771 molecules and the programmed cell death 1 protein (PD-1) and ecto-5'-nucleotidase (CD73) …

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A1, an innovative fluorinated CXCR4 inhibitor, redefines the therapeutic landscape in colorectal cancer

Hossein Khorramdelazad, Kowsar Bagherzadeh, Ali Rahimi, Ali Darehkordi et autres

BACKGROUND: Colorectal cancer (CRC) is a globally prevalent malignancy, primarily affecting the colon and rectum, characterized by uncontrolled cellular changes in the intestinal wall lining. Recent evidence underlines the significant role of the CXCL12/CXCR4 axis in the development of CRC, suggesting that …

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The expression changes of PD-L1 and immune response mediators are related to the severity of primary bone tumors

Amir Reza Eghtedari, Mohammad Amin Vaezi, Elaheh Safari, Vahid Salimi et autres

The expression pattern, diagnostic value, and association of PD-L1, IFN-γ and TGF-β with bone tumor type, severity, and relapse are determined in this study. 300 human samples from patients with osteosarcoma, Ewing sarcoma, and GCT were enrolled. The PD-L1 gene and protein …

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Purinergic signaling: decoding its role in COVID-19 pathogenesis and promising treatment strategies

Zahra Shafaghat, Amir-Hossein Khosrozadeh Ghomi, Hossein Khorramdelazad, Elaheh Safari

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Antitumor activities of a novel fluorinated small molecule (A1) in CT26 colorectal cancer cells: molecular docking and in vitro studies

Hossein Khorramdelazad, Kowsar Bagherzadeh, Ali Rahimi, Elaheh Safari et autres

Chemotherapeutic treatment of colorectal cancer (CRC) has not been satisfactory until now; therefore, the discovery of more efficient medications is of great significance. Based on available knowledge, the CXCL12/CXCR4 axis plays a significant role in tumorigenesis, and inhibition of CXCR4 chemokine receptor …

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Antitumor activities of a novel fluorinated small molecule (A1) in CT26 colorectal cancer cells: molecular docking and in vitro studies

Hossein Khorramdelazad, Kowsar Bagherzadeh, Ali Rahimi, Elaheh Safari et autres

Chemotherapeutic treatment of colorectal cancer (CRC) has not been satisfactory until now; therefore, the discovery of more efficient medications is of great significance. Based on available knowledge, the CXCL12/CXCR4 axis plays a significant role in tumorigenesis, and inhibition of CXCR4 chemokine receptor …

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Optimal Solution of the Fractional Order Breast Cancer Competition Model

Hossein Hassani, J. A. Tenreiro Machado, Z. Avazzadeh, Elaheh Safari et autres

Abstract This paper discusses the fractional order breast cancer competition model (F-BCCM), which considers population dynamics among cancer stem, tumor and healthy cells, as well as the effects of excess estrogen and the body’s natural immune response on the cell populations. Generalized …

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The effect of Candida cell wall beta-glucan on treatment-resistant LL/2 cancer cell line: in vitro evaluation

Fatemeh Sadeghi, Fatemeh Peymaeei, Mehraban Falahati, Elaheh Safari et autres

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The Effect of Teaching Cognitive Strategies on the Academic Achievement of Medical Students

Mohammad Hasan Keshavarzi, Elaheh Safari, Mehdi Shakarabi, Ali Shahrabi Farahani et autres

Introduction: Students' academic achievement is one of the important indicators in assessing university education.It seems that the use of cognitive strategies plays an important role in making desired changes in learning and academic achievements.Therefore, in this research, the effect of teaching cognitive …

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