Mihály Kovács

SSB1 links stress granule regulation to cellular stress responses and renal ischemia-reperfusion injury

János Pálinkás, Bálint Jezsó, Eszter Nagy‐Kanta, Rita Nemeth et autres

SUMMARY Mammalian single-stranded DNA binding protein 1 (SSB1) has been established as an essential component of genome stability in both human cells and mice. Moreover, SSB1 was recently implicated in cytoplasmic stress response by its involvement in Ras GTPase-activating protein-binding protein 1 …

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Fiatalok szakmaválasztási motivációi és döntési szempontjai a mezőgazdasági szakképzésben

Mihály Kovács

A kutatás kiindulópontja a középiskolai beiskolázás nehézségeinek személyes tapasztalata volt. Bár az iskola aktívan részt vesz pályaorientációs rendezvényeken és iskolalátogatásokon, ezek hatása nem tükröződik egyértelműen a jelentkezők számában. A probléma főként a mezőgazdasági szakképzésben jelentkezik, ahol a szakmák megítélése alacsony presztízsű, fizikailag …

Gráf László: Dörgicsétől Karachiig A trilógia befejező kötete. Emlékkönyv

Mihály Kovács, András Málnási‐Csizmadia, László Nyitray

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Phase transition of bacterial single-stranded DNA binding (SSB) protein upon stress response and metabolic adaptation

Péter Ecsédi, Júlia Szittyai, János Pálinkás, Bálint Jezsó et autres

Abstract Single-stranded DNA-binding proteins (SSBs) are ubiquitous factors of genome metabolism, recently recognized for their ability to undergo liquid–liquid phase separation (LLPS). While Escherichia coli SSB (EcSSB) has emerged as a model for bacterial LLPS in vitro , its phase behavior and …

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Comprehensive SAR analysis of actomyolytics, drug candidates targeting the actomyosin complex

Sharad Kumar Suthar, Tamás Szimler, Máté Pénzes, Sushmitha Chandrabhas et autres

There is a long-standing need for inhibitors that selectively target the actomyosin complex, the terminal effector of diverse processes that involve movement in the cells or the body. Such compounds, we term as actomyolytics , hold promise for treating numerous conditions with …

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Selective engineering of condensation properties of single-stranded DNA binding (SSB) protein via its intrinsically disordered linker region

Péter Ecsédi, Dávid Érfalvy, Zoltán J. Kovács, Viktoria Katran et autres

Single-stranded DNA binding (SSB) proteins are essential components of genome metabolism in both bacteria and eukaryotes. Recently demonstrated condensation propensities have placed SSB functions in a new context regarding the organization of nucleic acid-modifying complexes. In this work, we provide functional dissection …

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Fine‐tuned interactions between globular and disordered regions of single‐stranded DNA binding ( SSB ) protein are required for dynamic condensation under physiological conditions

Zoltán J. Kovács, Péter Ecsédi, Gábor M. Harami, János Pálinkás et autres

Abstract Increasing evidence points to the importance of liquid–liquid phase separation (LLPS)‐driven protein condensation in both eukaryotic and bacterial cell physiology. The formation of condensates may involve interactions between both structured (globular) domains and intrinsically disordered protein regions and requires multivalency that …

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Biblical Parallels and Christian Symbolism in C.S. Lewis’s The Lion, the Witch and the Wardrobe

Mihály Kovács

In my thesis, I searched for parallels between the Bible and C. S. Lewis's novel, The Lion, the Witch and the Wardrobe. I have found several symbols in the book which are probably based on the Bible. These symbols include characters, events …

Fine-tuned interactions between globular and disordered regions of single-stranded DNA binding (SSB) protein are required for dynamic condensation under physiological conditions

Zoltán J. Kovács, Péter Ecsédi, Gábor M. Harami, János Pálinkás et autres

Increasing evidence points to the importance of liquid-liquid phase separation (LLPS)-driven protein condensation in both eukaryotic and bacterial cell physiology. The formation of condensates may involve interactions between both structured (globular) domains and intrinsically disordered protein regions and requires multivalency that is …

Redox-dependent condensation and cytoplasmic granulation by human ssDNA-binding protein-1 delineate roles in oxidative stress response

Gábor M. Harami, János Pálinkás, Zoltán J. Kovács, Bálint Jezsó et autres

Human single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) plays central roles in DNA repair. Here, we show that purified hSSB1 undergoes redox-dependent liquid-liquid phase separation (LLPS) in the presence of single-stranded DNA or RNA, features that are distinct from those of LLPS by …

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Werner helicase interacting protein 1 contributes to G-quadruplex processing in human cells

Lili Hegedűs, Ágnes Tóth, Gábor M. Harami, János Pálinkás et autres

Genome replication is frequently impeded by highly stable DNA secondary structures, including G-quadruplex (G4) DNA, that can hinder the progression of the replication fork. Human WRNIP1 (Werner helicase Interacting Protein 1) associates with various components of the replication machinery and plays a …

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DNA ‐dependent phase separation by human SSB2 ( NABP1 / OBFC2A ) protein points to adaptations to eukaryotic genome repair processes

Zoltán J. Kovács, Gábor M. Harami, János Pálinkás, Natalie Kuljanishvili et autres

Single-stranded DNA binding proteins (SSBs) are ubiquitous across all domains of life and play essential roles via stabilizing and protecting single-stranded (ss) DNA as well as organizing multiprotein complexes during DNA replication, recombination, and repair. Two mammalian SSB paralogs (hSSB1 and hSSB2 …

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