Laura González-Cano

A mesh microelectrode array for non-invasive electrophysiology within neural organoids

Matthew G. McDonald, David Sebinger, Lisa Brauns, Laura González-Cano et autres

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Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease

Anna M. Speicher, Lisanne Korn, Júlia Csatári, Laura González-Cano et autres

Microglia, the resident immune cells of the central nervous system (CNS), are derived from yolk-sac macrophages that populate the developing CNS during early embryonic development. Once established, the microglia population is self-maintained throughout life by local proliferation. As a scalable source of …

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The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1

Jonas Walter, Silvia Bolognin, Suresh Kumar Poovathingal, Stefano G. Magni et autres

Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in a model of Parkinson's disease (PD). We monitor the differentiation of human patient-specific neuroepithelial stem …

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A mesh microelectrode array for non-invasive electrophysiology within neural organoids

Matthew G. McDonald, David Sebinger, Lisa Brauns, Laura González-Cano et autres

Abstract Organoids are emerging in vitro models of human physiology. Neural models require the evaluation of functional activity of single cells and networks, which is best measured by microelectrode arrays. The characteristics of organoids clash with existing in vitro or in vivo …

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Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

Jonas Walter, Silvia Bolognin, Paul M. A. Antony, Sarah Nickels et autres

Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of mitochondrial homeostasis has been highlighted as a crucial cofactor in its etiology. Here, we show that PD patient-specific human neuroepithelial stem cells …

lu, pt, no, us (code pays fourni par la source)

Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32

Laura González-Cano, Ingeborg Menzl, Johan Tisserand, Sarah Nicklas et autres

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Accumulating evidences suggest that PD might have a strong neurodevelopmental component. Among the genetic cases, mutations in the leucine-rich repeat kinase 2 (LRRK2) are well known to be disease causing. Although the …

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Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32

Maria Angeliki S. Pavlou, Nicolò Colombo, Sandra Fuertes-Álvarez, Sarah Nicklas et autres

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Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone

Eva Christine Bunk, Gökhan Ertaylan, Felipe Ortega, Maria Angeliki S. Pavlou et autres

Adult neural stem cells with the ability to generate neurons and glia cells are active throughout life in both the dentate gyrus (DG) and the subventricular zone (SVZ). Differentiation of adult neural stem cells is induced by cell fate determinants like the …

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p73 is required for ependymal cell maturation and neurogenic SVZ cytoarchitecture

Laura González-Cano, Sandra Fuertes-Álvarez, Natalia Robledinos-Antón, Alexandra Bizy et autres

The adult subventricular zone (SVZ) is a highly organized microenvironment established during the first postnatal days when radial glia cells begin to transform into type B-cells and ependymal cells, all of which will form regenerative units, pinwheels, along the lateral wall of …

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TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability

Lamiaa Bahnassawy, Thanneer Malai Perumal, Laura González-Cano, Anna‐Lena Hillje et autres

Induced pluripotent stem cells (iPSCs) have revolutionized the world of regenerative medicine; nevertheless, the exact molecular mechanisms underlying their generation and differentiation remain elusive. Here, we investigated the role of the cell fate determinant TRIM32 in modulating such processes. TRIM32 is essential …

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The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs

Sarah Nicklas, Satoshi Okawa, Anna‐Lena Hillje, Laura González-Cano et autres

In neural stem cells (NSCs), the balance between stem cell maintenance and neuronal differentiation depends on cell-fate determinants such as TRIM32. Previously, we have shown that TRIM32 associates with the RNA-induced silencing complex and increases the activity of microRNAs such as Let-7a. …

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p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF and TGFβ signaling

Rosalía Fernández-Alonso, Marta Martín‐López, Laura González-Cano, Sara P. Garcia et autres

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