Accès ouvert
2024
article
OpenAlex
Matthäus Bauer, Andreas S. Buser, C. Dierks, Susan Halimeh et autres
Zusammenfassung Zielsetzung Die Pathogeninaktivierung (PI) ist ein weltweit anerkanntes Verfahren zur Verbesserung der Sicherheit von Thrombozytenkonzentraten und Plasma. Diese Arbeit untersucht die Notwendigkeit und potenziellen Vorteile der Implementierung der PI für Thrombozytenkonzentrate in Deutschland. Methodik Analysiert werden sowohl Daten zur aktuellen Blutversorgung …
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Accès ouvert
2024
article
OpenAlex
Laura Infanti, Gerda C. Leitner, Morten K. Moe, Vildana Pehlic et autres
Background Elevated serum ferritin with/without HFE variants in asymptomatic persons leads frequently to referral for blood donation. Hemochromatosis (p.C282Y/p.C282Y) only requires treatment. We evaluated safety and feasibility of iron removal in healthy persons with elevated ferritin and HFE variants using blood donation …
ch, at, no
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Accès ouvert
2024
article
OpenAlex
Pierre Raeven, Katharina Karlhofer, Larissa Sztulman, Jonas Brugger et autres
Extracellular vesicles (EVs) accumulate during packed red blood cell (PRBC) storage. To date, the involvement of EVs in transfusion-related immunomodulation (TRIM) has not been prospectively evaluated in intensive care unit (ICU) patients. This was a prospective subanalysis of a recent observational feasibility …
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Accès ouvert
2023
article
OpenAlex
Pierre Raeven, Gerhard Hagn, Laura Niederstaetter, Jonas Brugger et autres
Introduction: Eicosanoids are bioactive lipids present in packed red blood cells (PRBCs), and might play a role in transfusion-related immunomodulation (TRIM). We tested the feasibility of analyzing eicosanoid profiles in PRBC supernatant and in plasma samples of postoperative intensive care unit (ICU) …
at
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Accès ouvert
2022
article
OpenAlex
Gerda C. Leitner, Gerhard Hagn, Laura Niederstaetter, Andrea Bileck et autres
Pathogen inactivation techniques for blood products have been implemented to optimize clinically safe blood components supply. The INTERCEPT system uses amotosalen together with ultraviolet light wavelength A (UVA) irradiation. Irradiation-induced inactivation of nucleic acids may actually be accompanied by modifications of chemically …
at
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Accès ouvert
2022
article
OpenAlex
Thomas Perkmann, Thomas Köller, Nicole Perkmann‐Nagele, Mária Ozsvár-Kozma et autres
BACKGROUND: Serological tests are widely used in various medical disciplines for diagnostic and monitoring purposes. Unfortunately, the sensitivity and specificity of test systems are often poor, leaving room for false-positive and false-negative results. However, conventional methods were used to increase specificity and …
at, gb
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Accès ouvert
2022
article
OpenAlex
Laura Infanti, Gerda C. Leitner, Morten K. Moe, Vildana Pehlic et autres
We analysed iron biomarkers and their relationships in 30 subjects with HFE mutations and moderate hyperferritinaemia undergoing iron removal at our blood donation centre. Body mass index (BMI) and liver enzymes were assessed. Serum iron (SI), ferritin, transferrin saturation (TSAT), hepcidin and …
ch, at, no
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Accès ouvert
2022
preprint
OpenAlex
Gerda C. Leitner, Gerhard Hagn, Laura Niederstätter, Andrea Bileck et autres
Abstract Gamma-irradiation of blood products is mandatory to avoid graft versus host disease in patients with immunosuppressed clinical conditions. Pathogen inactivation techniques were implemented to optimize safe blood component supply. The INTERCEPT treatment uses amotosalen together with UVA irradiation. The functional and …
at
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Accès ouvert
2022
article
OpenAlex
Johannes Gökler, A. Aliabadi-Zuckermann, Andreas Oliver Zuckermann, Emilio Osorio‐Jaramillo et autres
In severely ill patients undergoing urgent heart transplant (HTX), immunosuppression carries high risks of infection, malignancy, and death. Low-dose immunosuppressive protocols have higher rejection rates. We combined extracorporeal photopheresis (ECP), an established therapy for acute rejection, with reduced-intensity immunosuppression. Twenty-eight high-risk patients …
at
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Accès ouvert
2021
article
OpenAlex
Miriam Klausberger, Mark Duerkop, Helmuth Haslacher, Gordana Wozniak‐Knopp et autres
BACKGROUND: Antibody tests are essential tools to investigate humoral immunity following SARS-CoV-2 infection or vaccination. While first-generation antibody tests have primarily provided qualitative results, accurate seroprevalence studies and tracking of antibody levels over time require highly specific, sensitive and quantitative test setups. …
at, be, de, gb
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Accès ouvert
2021
preprint
OpenAlex
Miriam Klausberger, Mark Dürkop, Helmuth Haslacher, Gordana Wozniak‐Knopp et autres
Abstract Antibody tests are essential tools to investigate humoral immunity following SARS-CoV-2 infection. While first-generation antibody tests have primarily provided qualitative results with low specificity, accurate seroprevalence studies and tracking of antibody levels over time require highly specific, sensitive and quantitative test …
at, be, de, gb
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Accès ouvert
2021
article
OpenAlex
Bernd Georg Stegmayr, Elizabeth Newman, Volker Witt, Kurt Derfler et autres
Therapeutic apheresis (TA) is prescribed to patients that suffer from a severe progressive disease that is not sufficiently treated by conventional medications. A way to gain more knowledge about this treatment is usually by the local analysis of data. However, the use …
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