Seung Pil Yun

Emerging STAT1 post-translational modifications: mechanisms and translational perspectives

Suyeol Im, So Eun Lee, Bumseok Kim, Seung Pil Yun et autres

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A Cerebral Organoid Model of Familial Alzheimer’s Disease Using Amyloid Precursor Protein Mutation, Val669Leu ( APP Seoul )

Won Hee Jung, Seung Tack Oh, Mu Seog Choe, Yu Jin Kwon et autres

Won Hee Jung, Seung Tack Oh, Mu Seog Choe, Yu Jin Kwon, So Jin Kim, Ye Seong Jeon, Kyung Min Baek, Woochul Chang, Kyung Seob Lim, Joong Sun Kim, Seung Pil Yun, Min Young Lee. IJSC -0001;0:. https://doi.org/10.15283/ijsc25044

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Elevated CD45+CD11c+CX3CR1+ Cells in Optic Nerves and Their Relation to Optic Nerve Function in an Experimental Autoimmune Encephalomyelitis Model

Hyuna Kim, Jin Hyun Kim, Woong-Sun Yoo, Mee young Choi et autres

Dendritic cells are antigen-presenting cells that play essential roles in immunity and initiate immune reactions in experimental autoimmune encephalomyelitis (EAE) models. Dendritic cell recruitment was quantified in the optic nerve and retina after inducing the EAE model, and the correlation between functional …

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Identification of Common Genes Regulated by ER Stress During the Development of Diabetic Nephropathy Based on Human Transcriptome Datasets and an In Vivo Mouse Model

Jacques Karekezi, Ashimwe Yves Roger, Harry Jang, Jong‐Won Kim et autres

Diabetic nephropathy (DN) is a serious complication in diabetic patients, leading to kidney dysfunction and ultimately end-stage renal disease. Although several pharmacological agents have been developed, treating DN remains challenging due to its complex and multifaceted pathogenesis. Endoplasmic reticulum (ER) stress plays …

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The double-edged sword of regulatory T cells in MASLD: from inflammation control to fibrosis promotion

So Eun Lee, Min Gi Jo, Seong-Jin Park, Hye Jung Kim et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced inflammatory subtype, metabolic dysfunction-associated steatohepatitis (MASH), are becoming increasingly prevalent liver disorders driven by complex interactions between metabolic stress, immune dysregulation, and fibrotic remodeling. Regulatory T cells (Tregs), traditionally recognized for their immunosuppressive …

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Infosomes as Inflammatory Mediators: Proteomic Profiling of Proteins Enriched in Inflammatory Extracellular Vesicles

Semin Lee, Minjun Kim, Seungmin Lee, Hyo-Jin Kim et autres

Extracellular vesicles (EVs), including exosomes and microvesicles, act as transmitters of various biological signals through cell-cell communication. Although EVs derived from immune response cells have been partially studied, the characteristics of EVs mediated by NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation …

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ERK- and p53-Mediated ATF3 Expression Contributes to Cisplatin-Induced DNA Damage in Renal Epithelial Cells

Semin Lee, Minjun Kim, Seungmin Lee, Jiyun Yoo et autres

Objective: Cisplatin is a widely used chemotherapeutic agent due to its ability to damage DNA in the treatment of cancer. However, its clinical application is often limited by adverse effects on normal tissues, especially th... | Find, read and cite all the …

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Alterations in hematological, biochemical, and immune parameters in body fluids following low-dose-rate radiation exposure in mice

Eun‐Jin Kim, Long Cao Dang, Eun‐Ha Koh, Joong‐Sun Kim et autres

PURPOSE: Low-dose-rate (LDR) radiation is known to induce subtle biological effects, but its impact on body fluid-based biomarkers remains poorly defined. This study evaluated dose rate-dependent hematological, biochemical, and immunological changes in blood, peritoneal lavage fluid (PLF), and bronchoalveolar lavage fluid (BALF) …

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High-Intensity Interval Exercise Regulates Neurotrophic Factors and Astrocyte Activity in the Hippocampus and Cerebral Cortex

Junyoung Hong, Seon‐Hee Kim, Jiyeon Kim, Changsun Kim et autres

PURPOSE: Exercise training is widely recognized as a complementary intervention that provides both therapeutic and preventive benefits for neurodegenerative diseases, given its strong association with brain health. Regulating the expression of neurotrophic factors can significantly enhance cognitive function and memory processes, particularly …

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Cognitive and emotional dysregulation in T-cell-deficient mice: the role of hippocampal neurogenesis and synaptic plasticity

Bokyung Jung, Sohee Jeong, Changjong Moon, Hae‐June Lee et autres

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A2AR-phospho-STAT1 (Y701)-HLA-E axis as a potential immune modulatory pathway in radiotherapy-resistant triple negative breast cancer

Gyung Hyuck Ko, Hana Jin, Ju Won, Jong Sil Lee et autres

Triple-negative breast cancer (TNBC) patients have lower survival rates and higher recurrence risks than non-TNBC patients. Moreover, radiotherapy-resistant TNBC (RT-R-TNBC) exhibits enhanced chemotherapy resistance and invasiveness. Therefore, there is a critical need for innovative treatments for RT-R-TNBC and TNBC patients. Our previous …

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Periostin Deletion Reduces Corneal Opacity and the Infiltration of Immune Cells

Hyemin Seong, Chieun Song, Mingyo Kim, Woong-Sun Yoo et autres

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