High-Intensity Interval Exercise Regulates Neurotrophic Factors and Astrocyte Activity in the Hippocampus and Cerebral Cortex
Rattachement africain : us, kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
PURPOSE: Exercise training is widely recognized as a complementary intervention that provides both therapeutic and preventive benefits for neurodegenerative diseases, given its strong association with brain health. Regulating the expression of neurotrophic factors can significantly enhance cognitive function and memory processes, particularly in conditions such as Alzheimer’s disease (AD). However, the effects of high-intensity interval aerobic exercise training (HIE) on brain-derived neurotrophic factors and astrocyte activation in the cortex (CTX) and the hippocampus (HIP) remain unclear. Therefore, this study aimed to investigate whether HIE regulates the expression of neurotrophic factors and neuroinflammatory cytokines in the CTX and HIP.METHODS: Eighteen-week-old female C57BL/6 mice were assigned to control (Cnt) and HIE groups. After 12 weeks of HIE, the brains were harvested for immunoblotting, immunofluorescence, real-time PCR (qRT-PCR), and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays.RESULTS: HIE increased the expression of glial cell line-derived neurotrophic factor (GDNF) protein in the CTX but not in the HIP. Additionally, HIE exerted a protective effect against neuroinflammation by significantly upregulating A2-specific astrocytic transcripts. These findings suggest that HIE promotes neurotrophic and anti-inflammatory responses in both CTX and HIP.CONCLUSIONS: Our study results suggest that HIE exerts protective regulatory effects on neurotrophic factors, neuroinflammation, and A1/A2 type astrocytic reactivity in CTX and HIP of animal models. These findings suggest that HIE has beneficial effects on brain health. However, as these results were derived from animal studies, further clinical research is required to determine whether similar neuroprotective effects can be observed in humans.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- High-Intensity Interval Exercise Regulates Neurotrophic Factors and Astrocyte Activity in the Hippocampus and Cerebral Cortex
- Date Crossref
- 28/11/2025
- Éditeur
- Korean Society of Exercise Physiology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Cleveland Clinic Lerner College of Medicine Department of Pharmacology pays non établi dans la noticeÉtablissement de santé
-
Gyeongsang National University pays non établi dans la noticeUniversité ou école supérieure
-
Inha University Institute of Sports & Arts Convergence (ISAC) pays non établi dans la noticeUniversité ou école supérieure
-
Dongduk Women's University Department of Physical Education pays non établi dans la noticeUniversité ou école supérieure
-
Soonchunhyang University pays non établi dans la noticeUniversité ou école supérieure
-
Lerner Research Institute Department of Cardiovascular and Metabolic Sciences pays non établi dans la noticeStructure de recherche
Department of Pharmacology — Cleveland Clinic Lerner College of Medicine, Gyeongsang National University et Institute of Sports & Arts Convergence (ISAC) — Inha University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.