Junyoung Hong

Impact of TLR3 Activation on Endothelial Functions: Insights into iNOS- Dependent Mechanisms

Junchul Shin, Junyoung Hong, Soon‐Gook Hong, Jinkyung Cho et autres

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Phenylacetic Acid, a Gut Microbially Produced Metabolite, Reduces Atherosclerosis Burden and Impacts Host Lipid Homeostasis

Kelley M. Carr, Jiyeon Kim, Junchul Shin, Kathryn A. Bacik et autres

BACKGROUND: Gut microbial metabolism of dietary phenylalanine produces phenylacetic acid (PAA), followed by the host conversion to phenylacetylglutamine in humans and phenylacetylglycine in mice. Phenylacetylglutamine was linked to cardiovascular disease risk in multiple clinical studies, yet whether the microbial pathways leading to …

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Rejuvenation Potential of Developmental Genes Downregulated in Aging

Byungkuk Min, Juhyeon Nam, Minseo Choi, Junyoung Hong et autres

Partial reprogramming with Yamanaka factors effectively reverses cellular aging but poses potential oncogenic risks, limiting clinical translation. To identify safer rejuvenation induction factors (RIFs), we integrated five aging datasets and compared them with single-cell transcriptomics data from 811 mouse embryonic cells in …

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High-Intensity Interval Exercise Regulates Neurotrophic Factors and Astrocyte Activity in the Hippocampus and Cerebral Cortex

Junyoung Hong, Seon‐Hee Kim, Jiyeon Kim, Changsun Kim et autres

PURPOSE: Exercise training is widely recognized as a complementary intervention that provides both therapeutic and preventive benefits for neurodegenerative diseases, given its strong association with brain health. Regulating the expression of neurotrophic factors can significantly enhance cognitive function and memory processes, particularly …

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Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia

Junyoung Hong, Miguel Martín‐Aragón Baudel, Sayeman Islam Niloy, Jade L. Taylor et autres

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y 11L (P2Y 11 -like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kinase A)/Ca V 1.2 (L-type voltage-dependent calcium channel 1.2) nanocomplex in arterial myocytes, but upstream mechanisms are unclear. We …

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Physiological change of striatum and ventral midbrain's glia cell in response to different exercise modalities

Min Gi Jo, Junyoung Hong, Seon‐Hee Kim, So Eun Lee et autres

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α1 C S1928 Phosphorylation of Ca V 1.2 Channel Controls Vascular Reactivity and Blood Pressure

Víctor A. Flores-Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Jade L. Taylor et autres

Background Increased vascular Ca V 1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothesize that α1 C phosphorylation at serine 1928 …

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Exercise Training Mitigated Aortic Dysfunction In Mice With Alzheimer's Disease: Its Underlying Mechanisms

Junghoon Lee, Junyoung Hong

Emerging evidence has seen cerebrovascular pathology as the primary trigger for Alzheimer's disease (AD). Cerebrovascular dysfunction and amyloid-beta (Aβ) deposition are associated with stiffened aorta in AD. Thus, restoring aortic function could be a fundamental solution for the treatment and prevention of …

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Prolonged Hypoxic Exposure Impairs Endothelial Functions: Possible Mechanism of HIF-1α Signaling

Junyoung Hong, Junchul Shin

PURPOSE: Hypoxic training enhances oxygen availability by elevating hemoglobin, red blood cells, and capillaries. hypoxia-inducible factor (HIF) stabilization under hypoxic conditions triggers glycolysis, erythropoiesis, and angiogenesis. However, prolonged hypoxic exposure causes endothelial cell dysfunction, contributing to cardiovascular diseases. Furthermore, endothelial mitochondria play …

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Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice

Cynthia Alicia Traughber, Kara Timinski, Ashutosh Prince, Nilam Bhandari et autres

Background Pyroptosis executor GsdmD (gasdermin D) promotes atherosclerosis in mice and humans. Disulfiram was recently shown to potently inhibit GsdmD, but the in vivo efficacy and mechanism of disulfiram's antiatherosclerotic activity is yet to be explored. Methods and Results We used human/mouse …

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Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels

Junyoung Hong

Background: Exercise training elicits indubitable positive adaptation in microcirculation in health and disease populations. An inclusive overview of the current knowledge regarding the effects of exercise on microvascular function consolidates an in-depth understanding of microvasculature. Summary: The main physiological function of microvasculature …

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Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured Cells

Junchul Shin, Junyoung Hong, Jonnelle M. Edwards, Irene Krukovets et autres

BACKGROUND: Biological sex differences play a vital role in cardiovascular diseases, including atherosclerosis. The endothelium is a critical contributor to cardiovascular pathologies since endothelial cells (ECs) regulate vascular tone, redox balance, and inflammatory reactions. Although EC activation and dysfunction play an essential …

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