Infosomes as Inflammatory Mediators: Proteomic Profiling of Proteins Enriched in Inflammatory Extracellular Vesicles
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Le résumé fourni par la source
Extracellular vesicles (EVs), including exosomes and microvesicles, act as transmitters of various biological signals through cell-cell communication. Although EVs derived from immune response cells have been partially studied, the characteristics of EVs mediated by NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation remain unclear. Here, we characterize inflammatory EVs, termed infosomes, derived from NLRP3 inflammasome-activated macrophages, which play a role in inducing inflammation. Proteomic analysis revealed that EV production was increased in macrophages with activated NLRP3 inflammasomes and that these EVs were enriched with marker proteins involved in metabolism, membrane structure, and cytoskeletal organization. Furthermore, significantly increased proteins were associated with signaling pathways and biological processes related to immune response, phagocytosis, endocytosis, and neurodegenerative diseases. Crucially, these alterations in EV secretion and molecular composition were dependent on NLRP3 and its subsequent inflammasome activity. Functionally, these infosomes were shown to amplify the expression of inflammatory factors in both macrophages and endothelial cells. These findings provide insights into the biological roles of infosomes, suggesting that EVs generated and loaded by NLRP3 inflammasome activation act as key biological mediators that disseminate and amplify inflammatory responses through cell-cell communication. This highlights their potential as novel biomarkers and therapeutic targets for inflammatory diseases.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Infosomes as Inflammatory Mediators: Proteomic Profiling of Proteins Enriched in Inflammatory Extracellular Vesicles
- Date Crossref
- 01/02/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Gyeongsang National University Division of Applied Life Science pays non établi dans la noticeUniversité ou école supérieure
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Yale University pays non établi dans la noticeUniversité ou école supérieure
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Kyungpook National University pays non établi dans la noticeUniversité ou école supérieure
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College of Medicine Department of Biochemistry pays non établi dans la noticeUniversité ou école supérieure
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College of Pharmacy and Research Institute of Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Internal Medicine Yale School of Medicine Critical Care and Sleep Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Life Sciences BK21 FOUR KNU Creative BioResearch Group pays non établi dans la noticeUniversité ou école supérieure
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College of Veterinary Medicine Department of Veterinary Obstetrics pays non établi dans la noticeUniversité ou école supérieure
Division of Applied Life Science — Gyeongsang National University, Yale University et Kyungpook National University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.