Lucia Finaurini

Point‐of‐Care White Blood Cell Differential Testing in Pediatric Inpatients (2 Months–17 Years): How Does HemoScreen Perform?

Alessio Correani, Beatrice NICCOLETTI, Marianna Pavani, Michela Sampaolo et autres

BACKGROUND: Point-of-care (POC) hematology testing is of growing interest in pediatric practice. We previously evaluated an image-based POC hematology analyzer (HemoScreen, PixCell Medical, Yokneam Illit, Israel) for total white blood cell (WBC), red blood cell, and platelet counts and associated indices in …

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Hemoscreen Point‐of‐Care Analyzer Compared With Sysmex XN‐1000 for Complete Blood Count in Pediatric Inpatients Aged 2 Months to 17 Years

Alessio Correani, Beatrice NICCOLETTI, Marianna Pavani, Michela Sampaolo et autres

INTRODUCTION: HemoScreen is an image-based point-of-care (POC) hematology analyzer that performs complete blood counts (CBC) from small blood volumes with minimal handling. These features are particularly relevant in pediatrics; however, comparative evidence with central laboratory analyzers in children remains limited. METHODS: -EDTA …

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Morfologia digitale con tecnologia CellaVision®: modelli organizzativi applicati al laboratorio di ematologia

Marco Moretti, Lucia Finaurini, Michela Sampaolo, Maria Cristina Puzzolo et autres

In a previous article entitled “Digital morphology and blood cell count” the general features of digital morphology systems dedicated to diagnostic hematology currently available have been described. The purpose of this paper is to provide to the reader an overview of several …

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Leucemia plasmacellulare: primo inquadramento diagnostico in laboratorio

Lidia DA LIO, Michela Sampaolo, Lucia Finaurini, Sonia Morè et autres

The laboratory hematology represents an indispensable aid to clinical hematology. The clinical case of a 66-year-old woman admitted to the emergency department for non-specific symptomatology characterized by fever, asthenia and dyspnea on exertion is reported here. The CBC and DIFF examination was …

Il middleware ematologico: supporto e opportunità nella determinazione dell’emoglobina glicata

Marco Moretti, Barbara Pieretti, Maria Rita Sadori, Daniela Sbrozzi et autres

Le facilitazioni e le potenzialità informatiche, il loro sviluppo e governo sono elementi fondamentali per garantire una diagnostica di laboratorio di qualità e al passo con i tempi. La standardizzazione dei comportamenti, la tracciabilità, l’integrazione delle informazioni e la disponibilità in rete …

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Epidemiology, diagnosis and management of superficial mycoses: ours three years retrospective analysis

Barbara Pieretti, Marco Moretti, Maria Rita Sadori, Daniela Sbrozzi et autres

Mycotic infections of the skin, hair and nails are disorder with high prevalence. Dermatophytes are the most frequently etiologic agents followed by yeasts and non-dermatophyte moulds. The geographic distribution is variable because of migration, lifestyle and socio-economics conditions. In this study, based …

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A Novel Fold Revealed by Mycobacterium tuberculosis NAD Kinase, a Key Allosteric Enzyme in NADP Biosynthesis

Silvia Garavaglia, Nadia Raffaelli, Lucia Finaurini, Giulio Magni et autres

NAD kinase catalyzes the magnesium-dependent phosphorylation of NAD, representing the sole source of freshly synthesized NADP in all organisms. The enzyme is essential for the growth of the deadly multidrug-resistant pathogen Mycobacterium tuberculosis and is an attractive target for novel antitubercular agents. …

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Crystal structure of Mycobacterium tuberculosis NAD kinase

Silvia Garavaglia, Nadia Raffaelli, Lucia Finaurini, Giulio Magni et autres

Characterization of Mycobacterium tuberculosis NAD Kinase: Functional Analysis of the Full-Length Enzyme by Site-Directed Mutagenesis

Nadia Raffaelli, Lucia Finaurini, Francesca Mazzola, Lisa Pucci et autres

NAD kinase is the only known enzyme catalyzing the formation of NADP, a coenzyme implicated in most reductive biosynthetic reactions and in many antioxidant defense systems. Despite its importance, nothing is known regarding its structure or mechanism of catalysis. Mycobacterium tuberculosis NAD …

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