Mario Castro

Identificación de colonizadores bacterianos precoces en recién nacidos muy bajo peso

Catalina Vaz Ferreira, Josefina Vera, Nadia Riera, Mario Castro

La mortalidad en los recién nacidos muy bajo peso (RNMBP) representa hasta el 50%-70% de la mortalidad neonatal y hasta el 25%-30% de la mortalidad infantil. A pesar del aumento global en las tasas de sobrevida, esta población sigue presentando un riesgo …

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Association of long COVID with health-related quality-of-life outcomes

Michael Gelman, Susana Moyano, Larisha Pillay-Ramaya, Eugene Bukhman et autres

The association of long COVID with health-related quality-of-life (HrQOL) has not been well-characterized. Participants who received blinded placebo in the ACTIV-2/A5401 outpatient COVID-19 treatment trial were included in an analysis of the association of long COVID with HrQOL (both pre-specified exploratory trial …

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Association of long COVID with health-related quality-of-life outcomes

Malini M. Gandhi, Carlee Moser, Judith S. Currier, Justin Ritz et autres

The association of long COVID with health-related quality-of-life (HrQOL) has not been well-characterized. Participants who received blinded placebo in the ACTIV-2/A5401 outpatient COVID-19 treatment trial were included in an analysis of the association of long COVID with HrQOL (both pre-specified exploratory trial …

us, Afrique du Sud, gb, ar, br, mx, ph (code pays fourni par la source)

High airway thymic stromal lymphopoietin in asthma is associated with type 2 inflammation, mucus plugging, and airway remodeling

Kritika Khanna, Monica Tang, Nathan D. Jackson, Mats W. Johansson et autres

BACKGROUND: Inhibition of thymic stromal lymphopoietin (TSLP) improves asthma control, but the relationships between airway TSLP levels and clinical and immunologic features of asthma are unclear. OBJECTIVE: We sought to determine associations between airway TSLP, disease control, and airway remodeling in asthma. …

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Harmonized low‐dose computed tomographic protocols for quantitative lung imaging using dose modulation and advanced reconstructions

Jarron Atha, Rachel L. Eddy, Junfeng Guo, John D. Newell et autres

BACKGROUND: Quantitative computed tomography (QCT) lung imaging is employed in many multi-center studies. Standardized protocols have used fixed volumetric CT dose index (CTDIvol) adjusted for body mass index to minimize dose while accounting for participant size. Dose modulation and iterative/deep-learning reconstruction (IR/DLR) …

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BASELINE TYPE 2 BIOMARKERS AS PREDICTORS OF MULTICOMPONENT CLINICAL REMISSION FOLLOWING DUPILUMAB TREATMENT IN PATIENTS WITH MODERATE-TO-SEVERE ASTHMA

Giorgio Walter Canonica, Ian Pavord, Simon Couillard, GUY G BRUSSELLE et autres

BRONCHIAL RHEOPLASTY FOR CHRONIC BRONCHITIS: RESULTS FROM THE RHESOLVE TRIAL

Frank C. Sciurba, William Krimsky, GERARD J CRINER, JONATHAN S KURMAN et autres

Obstructive Spirometric Index for Asthma Attack Risk Prediction: Analysis from the ORACLE2 Patient-Level Meta-Analysis

Samuel Mailhot-Larouche, Fleur L. Meulmeester, Sanjay Ramakrishnan, Michael E. Wechsler et autres

RATIONALE: Low lung function is a key risk factor for asthma attacks. While forced expiratory volume in 1 second (FEV₁) is widely used, it lacks specificity. Incorporating the FEV₁/forced vital capacity (FEV₁/FVC) ratio may better capture obstruction. AIM: To develop an index …

ca, nl, au, us, be, gb, in, nz (code pays fourni par la source)

Late Breaking Abstract - Bronchial Rheoplasty for Chronic Bronchitis: Results from the Randomized, Mechanical Sham-Controlled RheSolve Study

Arschang Valipour, Frank C. Sciurba, Anand Tana, Gerard J. Criner et autres

Introduction: Chronic bronchitis (CB), defined by persistent cough and mucus production, is a common chronic obstructive pulmonary disease (COPD) phenotype with a high symptom burden. Bronchial rheoplasty (BR) with RheOx® disrupts mucus and delivers pulsed electric fields (PEF) to airway epithelium to …

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Predictors of placebo response in asthma attack rates: analysis from the ORACLE2 patient-level meta-analysis

Samuel Mailhot-Larouche, Fleur L. Meulmeester, Sanjay Ramakrishnan, Michael Wechsler et autres

Rationale: In asthma randomised controlled trials (RCTs), a large placebo response hampers identification of treatment effects. Aim: To identify patient characteristics associated with placebo response in asthma attack rate in RCTs. Methods: We analyzed ORACLE2, a patient-level meta-analysis of RCT control arms, …

ca, nl, au, us, be, gb, in, nz (code pays fourni par la source)

Sex differences in clinical risk factors and type-2 biomarkers for predicting asthma attacks in the ORACLE2 patient-level meta-analysis

Sebastian Riemann, Fleur L. Meulmeester, Samuel Mailhot-Larouche, Sanjay Ramakrishnan et autres

Rationale: Multiple risk factors for asthma attacks have been identified, including clinical characteristics, blood eosinophil count (BEC), and exhaled nitric oxide (FeNO). However, the impact of sex on their prognostic value is unclear. Aim: To investigate sex differences in prognostic values of …

be, nl, ca, au, us, gb, fr, Cabo Verde, in, nz (code pays fourni par la source)

Sex-differences in airway transcriptomic signatures in asthma.

Joe Zein, Sarita Poonia, Lacey Nixon, Bo Hu et autres

To understand sex differences in asthma (A) across the ages, we assessed sex-differences in bronchial epithelial cells RNAseq data from 3 cohorts (SARP 3, GSE85567, GSE201955) and combined the results in a meta-analysis. We stratified our analysis by age (1: ≤50 years, …

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