Alison A. Bettis

CEPI Workshop Report: Applying Disease X Vaccine Library and Knowledge Base Approaches to Severe Fever with Thrombocytopenia Syndrome (SFTS)

Mitsutaka Kitano, Byoung-Shik Shim, Hitoshi Sasaki, Jonathan F. Lovell et autres

On 9-10 December 2025, the Coalition for Epidemic Preparedness Innovations (CEPI) and the International Vaccine Institute (IVI) convened a workshop in Seoul under CEPI's Disease X Program. The primary objective was to identify existing gaps needing to be filled and streamline vaccine …

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Strategic considerations on developing a CHIKV vaccine and ensuring equitable access for countries in need

Neil George Cherian, Alison A. Bettis, Arminder Deol, Arun Kumar et autres

Chikungunya is an arboviral disease caused by the chikungunya virus (CHIKV) afflicting tropical and sub-tropical countries worldwide. It has been identified as a priority pathogen by the Coalition for Epidemics Preparedness Innovations (CEPI) and as an emerging infectious disease (EID) necessitating further …

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Projecting vaccine demand and impact for emerging zoonotic pathogens

Anita Lerch, Quirine A. ten Bosch, Alison A. Bettis, Mauro Bernuzzi et autres

Abstract Background Despite large outbreaks in humans seeming improbable for a number of zoonotic pathogens, several pose a concern due to their epidemiological characteristics and evolutionary potential. To enable effective responses to these pathogens in the event that they undergo future emergence, …

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The global epidemiology of chikungunya from 1999 to 2020: A systematic literature review to inform the development and introduction of vaccines

Alison A. Bettis, Maïna L’Azou, In-Kyu Yoon, J. Gabrielle Breugelmans et autres

Chikungunya fever is an acute febrile illness that is often associated with severe polyarthralgia in humans. The disease is caused by chikungunya virus (CHIKV), a mosquito-borne alphavirus. Since its reemergence in 2004, the virus has spread throughout the tropical world and several …

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The increased sensitivity of qPCR in comparison to Kato-Katz is required for the accurate assessment of the prevalence of soil-transmitted helminth infection in settings that have received multiple rounds of mass drug administration

Julia C. Dunn, Marina Papaiakovou, Kay Thwe Han, Darren Chooneea et autres

BACKGROUND: The most commonly used diagnostic tool for soil-transmitted helminths (STH) is the Kato-Katz (KK) thick smear technique. However, numerous studies have suggested that the sensitivity of KK can be problematic, especially in low prevalence and low intensity settings. An emerging alternative …

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Productivity costs from a dengue episode in Asia: a systematic literature review

Trinh Manh Hung, Donald S. Shepard, Alison A. Bettis, Huyen Anh Nguyen et autres

BACKGROUND: Dengue is a mosquito-borne viral infection which has been estimated to cause a global economic burden of US$8.9 billion per year. 40% of this estimate was due to what are known as productivity costs (the costs associated with productivity loss from …

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Correction to: Developing vaccines against epidemic-prone emerging infectious diseases

Valentina Bernasconi, Paul A. Kristiansen, Mike Whelan, Raúl Gómez Román et autres

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Developing vaccines against epidemic-prone emerging infectious diseases

Valentina Bernasconi, Paul A. Kristiansen, Mike Whelan, Raúl Gómez Román et autres

Today's world is characterized by increasing population density, human mobility, urbanization, and climate and ecological change. This global dynamic has various effects, including the increased appearance of emerging infectious diseases (EIDs), which pose a growing threat to global health security.Outbreaks of EIDs, …

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The Health and Economic Burdens of Lymphatic Filariasis Prior to Mass Drug Administration Programs

Christopher G. Mathew, Alison A. Bettis, Brian K Chu, Mike English et autres

BACKGROUND: The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000 with the goal of eliminating lymphatic filariasis (LF) as a public health problem by 2020. Despite considerable progress, the current prevalence is around 60% of the 2000 figure, with …

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Soil-transmitted helminth reinfection four and six months after mass drug administration: results from the delta region of Myanmar

Julia C. Dunn, Alison A. Bettis, Nay Yee Wyine, Aye Moe Moe Lwin et autres

BACKGROUND: Mass drug administration (MDA), targeted at school-aged children (SAC) is the method recommended by the World Health Organization for the control of morbidity induced by soil-transmitted helminth (STH) infection in endemic countries. However, MDA does not prevent reinfection between treatment rounds …

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Valuing the Unpaid Contribution of Community Health Volunteers to Mass Drug Administration Programs

Hugo C. Turner, Jaspreet Toor, Alison A. Bettis, Adrian Hopkins et autres

Community health volunteers (CHVs) are being used within a growing number of healthcare interventions, and they have become a cornerstone for the delivery of mass drug administration within many neglected tropical disease control programs. However, a greater understanding of the methods used …

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The Estimates of the Health and Economic Burden of Dengue in Vietnam

Trinh Manh Hung, Hannah Clapham, Alison A. Bettis, Hoang Quoc Cuong et autres

Dengue has been estimated to cause a substantial health and economic burden in Vietnam. The most recent studies have estimated that it is responsible for 39884 disability-adjusted life years (DALYs) annually, representing an economic burden of US$94.87 million per year (in 2016 …

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