Lauren G. Falkenberg

743 Effects of environmental and social epidemiological factors on cytokine response in people with cystic fibrosis

Maria Ansar, Lauren G. Falkenberg, Cynthia Davidson, Vladimir Ustiyan et autres

TGF-β induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K

Cynthia Davidson, Vladimir Ustiyan, Lauren G. Falkenberg, Amulya Adavalli et autres

The etiology of IL-6 oversecretion in cystic fibrosis (CF) is unclear, as is the mechanism of CF lung disease modification by TGF-β. We show that TGF-β induces IL-6 oversecretion in human and mouse models of CF. In mechanistic studies, we further demonstrate …

us (code pays fourni par la source)

Ccdc103 promotes myeloid cell proliferation and migration independent of motile cilia

Lauren G. Falkenberg, Sarah Beckman, Padmapriyadarshini Ravisankar, Tracy E. Dohn et autres

The pathology of primary ciliary dyskinesia (PCD) is predominantly attributed to impairment of motile cilia. However, PCD patients also have perplexing functional defects in myeloid cells, which lack motile cilia. Here, we show that coiled-coil domain-containing protein 103 (CCDC103), one of the …

us (code pays fourni par la source)

Cilia-independent requirements for Ccdc103 promoting proliferation and migration of myeloid cells

Lauren G. Falkenberg, Sarah Beckman, Padmapriyadarshini Ravisankar, Tracy E. Dohn et autres

Abstract The pathology of primary ciliary dyskinesia (PCD) is predominantly attributed to impairment of motile cilia. However, PCD patients also have perplexing functional defects in myeloid cells, which lack motile cilia. Here, we show Coiled-coiled domain containing protein 103 (CCDC103), mutations in …

us (code pays fourni par la source)

In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator

Enrico D’Aniello, Fabio Arturo Iannotti, Lauren G. Falkenberg, Andrea Martella et autres

The nuclear receptors (NRs) RARα, RXRα, PPARα, and PPARγ represent promising pharmacological targets for the treatment of neurodegenerative diseases. In the search for molecules able to simultaneously target all the above-mentioned NRs, we screened an in-house developed molecular database using a ligand-based …

it, us, ca (code pays fourni par la source)

Inhibition of HGF/MET signaling decreases overall tumor burden and blocks malignant conversion in Tpl2-related skin cancer

Nicole F. Bonan, David Kowalski, Kaitie Kudlac, Kira Flaherty et autres

Abstract Tumor progression locus 2 (Tpl2) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family of serine/threonine kinases. Deletion of the Tpl2 gene is associated with a significantly higher number of papillomas and cutaneous squamous cell carcinomas (cSCCs). Overexpression …

us (code pays fourni par la source)

Abstract 2809: Role of c-Met in the development and progression of Tpl2-related skin cancer

Nicole F. Bonan, David Kowalski, Kaitlin Kudlac, Lauren G. Falkenberg et autres

Abstract Cutaneous squamous cell carcinoma (cSCC), a form of non-melanoma skin cancer, is the second most common form of cancer in the United States, with over one million cases diagnosed annually. Tpl2 (MAP3K8) is a serine threonine protein kinase in the mitogen-activated …

us (code pays fourni par la source)

Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling

Erica M. Bullwinkle, Melissa D. Parker, Nicole F. Bonan, Lauren G. Falkenberg et autres

us (code pays fourni par la source)

Abstract 2071: Disruption of TGFβ-mediated tumor suppression in a Tpl2 model of cutaneous squamous cell carcinoma

Lauren G. Falkenberg, J. Curtis Gwilliam

Abstract Skin cancer is the most common form of cancer in the United States, with an estimated two million cases diagnosed annually, and incidence continues to increase. Tpl2 (Map3k8) is a serine threonine protein kinase in the mitogen-activated protein kinase (MAPK) signal …

us (code pays fourni par la source)

Abstract 3609: Fibroblast influence on keratinocyte tumorigenic and metastatic potential in cutaneous squamous cell carcinoma

J. Curtis Gwilliam, Alexander CVitan, Nicholas Watson, Lauren G. Falkenberg et autres

Abstract Skin cancer is the most common form of cancer in the United States, with an estimated two million cases diagnosed annually. Tpl2 (Map3k8) is a serine threonine protein kinase in the mitogen-activated protein kinase (MAPK) signal transduction cascade. Tpl2 was identified …

us (code pays fourni par la source)

Abstract 3857: Targeting HDAC1 in a novel model of cutaneous T-cell lymphoma.

Anjali Mishra, Laura A. Sullivan, Gregory H. Sams, Jessica Johns et autres

Abstract Cutaneous T-cell lymphoma (CTCL) is a type of non-Hodgkin's lymphoma composed of a spectrum of diseases of malignant clonal helper CD4+ T lymphocytes. Previous studies have shown that IL-15 acts as viability factor for CTCL cells, inhibiting apoptosis, and may work …

us (code pays fourni par la source)

Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation

Anjali Mishra, Shujun Liu, Gregory H. Sams, Douglas P. Curphey et autres

us (code pays fourni par la source)