Sarah Beckman

Disenfranchised social isolation in protracted displacement: Lessons from Georgia based on emotion analysis of social media data

Tina R. Kilaberia, Hamid Akbary, Sarah Beckman, Mohamad Adam Brooks

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Ccdc103 promotes myeloid cell proliferation and migration independent of motile cilia

Lauren G. Falkenberg, Sarah Beckman, Padmapriyadarshini Ravisankar, Tracy E. Dohn et autres

The pathology of primary ciliary dyskinesia (PCD) is predominantly attributed to impairment of motile cilia. However, PCD patients also have perplexing functional defects in myeloid cells, which lack motile cilia. Here, we show that coiled-coil domain-containing protein 103 (CCDC103), one of the …

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Cilia-independent requirements for Ccdc103 promoting proliferation and migration of myeloid cells

Lauren G. Falkenberg, Sarah Beckman, Padmapriyadarshini Ravisankar, Tracy E. Dohn et autres

Abstract The pathology of primary ciliary dyskinesia (PCD) is predominantly attributed to impairment of motile cilia. However, PCD patients also have perplexing functional defects in myeloid cells, which lack motile cilia. Here, we show Coiled-coiled domain containing protein 103 (CCDC103), mutations in …

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Assessing Phenotypic Changes in Zebrafish through Automated Quantitative Imaging

Peter Banks, Sarah Beckman

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Coiled‐coil domain containing protein 103 regulates myeloid development and function

Sarah Beckman, Josh Waxman

Rationale Abnormal myeloid function is implicated in many diseases, including leukemia, atherosclerosis and others. Therefore, understanding regulators of myelopoiesis and myeloid function will lead to novel therapies. We have identified that the poorly understood coiled‐coil domain containing protein 103 (Ccdc103) is expressed …

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The superior regenerative potential of muscle-derived stem cells for articular cartilage repair is attributed to high cell survival and chondrogenic potential

Hongshuai Li, Aiping Lu, Ying Margie Tang, Sarah Beckman et autres

Three populations of muscle-derived cells (PP1, PP3, and PP6) were isolated from mouse skeletal muscle using modified preplate technique and retrovirally transduced with BMP4/GFP. In vitro , the PP1 cells (fibroblasts) proliferated significantly slower than the PP3 (myoblasts) and PP6 cells (muscle-derived …

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NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair

Jonathan D. Proto, Ying Margie Tang, Aiping Lu, W C W Chen et autres

The transcription factor nuclear factor κB (NF-κB)/p65 is the master regulator of inflammation in Duchenne muscular dystrophy (DMD). Disease severity is reduced by NF-κB inhibition in the mdx mouse, a murine DMD model; however, therapeutic targeting of NF-κB remains problematic for patients …

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The Role of Antioxidation and Immunomodulation in Postnatal Multipotent Stem Cell-Mediated Cardiac Repair

Arman Saparov, Chien‐Wen Chen, Sarah Beckman, Yadong Wang et autres

Oxidative stress and inflammation play major roles in the pathogenesis of coronary heart disease including myocardial infarction (MI). The pathological progression following MI is very complex and involves a number of cell populations including cells localized within the heart, as well as …

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Beneficial Effect of Mechanical Stimulation on the Regenerative Potential of Muscle-Derived Stem Cells Is Lost by Inhibiting Vascular Endothelial Growth Factor

Sarah Beckman, Ying Margie Tang, Jonathan D. Proto, Logan Mlakar et autres

OBJECTIVE: We previously reported that mechanical stimulation increased the effectiveness of muscle-derived stem cells (MDSCs) for tissue repair. The objective of this study was to determine the importance of vascular endothelial growth factor (VEGF) on mechanically stimulated MDSCs in a murine model …

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Using Molecular Dynamics (MD) in modeling broadly neutralizing antibodies against influenza viruses and its implications for developing a “universal flu vaccine”

Will LaCosta, Sarah Beckman, J. E. Friend, Elliabeth Krautler et autres

Influenza evolves rapidly to evade existing human immunity and seasonal flu vaccines. The recent discovery of broadly neutralizing antibodies against influenza points to the possibility of “universal flu vaccines”, which may protect against viral strains over many seasons. The SMART team from …

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Muscle-derived Stem Cell Sheets Support Pump Function and Prevent Cardiac Arrhythmias in a Model of Chronic Myocardial Infarction

Naosumi Sekiya, Kimimasa Tobita, Sarah Beckman, Masaho Okada et autres

Direct intracardiac cell injection for heart repair is hindered by numerous limitations including: cell death, poor spreading of the injected cells, arrhythmia, needle injury, etc. Tissue-engineered cell sheet implantation has the potential to overcome some of these limitations. We evaluated whether the …

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Human Pericytes for Ischemic Heart Repair

Chien‐Wen Chen, Masaho Okada, Jonathan D. Proto, Xueqin Gao et autres

Human microvascular pericytes (CD146(+)/34(-)/45(-)/56(-)) contain multipotent precursors and repair/regenerate defective tissues, notably skeletal muscle. However, their ability to repair the ischemic heart remains unknown. We investigated the therapeutic potential of human pericytes, purified from skeletal muscle, for treating ischemic heart disease and …

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