Dobson Ruth

Genetic Determinants of Multiple Sclerosis Susceptibility in People From Diverse Ancestral Backgrounds

Benjamin M. Jacobs, Luisa Schalk, Emily Tregaskis-Daniels, Antonio Scalfari et autres

BACKGROUND AND OBJECTIVES: The genetic basis of multiple sclerosis (MS) susceptibility has been studied extensively in European (EUR) ancestry populations. The aim of our study was to determine the genetic architecture of MS susceptibility in people of South Asian (SAS) and African …

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A national survey of dementia diagnosis and care in English memory services

Oliver Kelsey, Harriet Demnitz-King, Charlotte Kenten, Hannah Chapman et autres

BACKGROUND: In England, National Health Service (NHS) memory services provide most dementia diagnostic and immediate post-diagnostic care. We aimed to co-design and conduct a survey regarding diagnostic and post-diagnostic care, and perceived readiness for new treatments. METHODS: We invited all memory services …

gb (code pays fourni par la source)

The Nottingham consensus on dementia risk reduction policy: recommendations from a modified Delphi process

Harriet Demnitz-King, SUBE BANERJEE, Claudia Cooper, Charlotte Kenten et autres

gb, kr, us, se (code pays fourni par la source)

Optimal strategies for treatment discontinuation in MOG antibody-associated disease

Wei Zhen Yeh, Anna Francis, Sarah Cooper, Waqar Rashid et autres

The relapse risk following discontinuation of immunomodulatory treatment in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unknown. Evidence suggests that 'at least' 3 months of oral corticosteroids reduces relapse risk after a single attack, and that it may be possible to stop …

gb, au, us (code pays fourni par la source)

Comorbidity and modifiable risk factors in multiple sclerosis

Yao Zhang, Dobson Ruth, G. Giovannoni

Multi-system comorbidities are common in patients with multiple sclerosis (PwMS) and significantly influence the disease's presentation and progression. A comorbidity is defined as an illness other than the specific disease of interest (in this case, MS). Generally, chronic or recurrent conditions are …

cn, gb (code pays fourni par la source)

National survey of older people’s community mental health teams in England

Malvika Muralidhar, Hannah Chapman, Oliver Kelsey, Jasmine Shaw et autres

Background The mental healthcare workforce supporting people with dementia and comorbid mental disorders requires specific skills and knowledge. Aims We co-designed and conducted a survey to understand key issues facing community mental healthcare services accessed by older adults. Method We invited all …

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Impact of multiple sclerosis risk alleles on the plasma proteome

Bernard Healey Shannon, Gavin Giovannoni, Noyce Alastair, Dobson Ruth et autres

Genetic analysis of multiple sclerosis (MS) susceptibility has implicated over 200 loci, however it remains unclear how genetic variants impact disease pathogenesis. Clarifying how MS-associated genetic variants affect the plasma proteome could help to identify druggable targets and elucidate disease pathobiology. We …

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Modifiable risk factors for multiple sclerosis are consistent across ethnic backgrounds

J. K. K. Benjamin, Bestwick Jonathan, Noyce Alastair, Marshall Charles et autres

Background Epidemiological studies conducted in majority White populations have identified multiple potentially modifiable risk factors for Multiple Sclerosis (MS). It is unknown whether these risk factors differ between ethnic groups. Methods We conducted a nested case-control study using data from the UK …

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T-cell response and COVID-19 infection following COVID-19 booster vaccinations in pwMS treated with ocrelizumab

Zaloum Safiya A, Upcott Matthew, Vickaryous Nicola, Scurr Martin J et autres

Introduction People with multiple sclerosis (pwMS) treated with ocrelizumab mount a T-cell response to vaccination, irrespective of humoral response. Correlates of this pattern of immune response remain unclear. Methods PwMS on ocrelizumab who were seronegative following initial COVID-19 vaccine course provided whole …

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OPTIMISE-MS: real-world safety of disease-modifying therapies for multiple sclerosis

Jacobs Benjamin, Waddingham Ed, Craner Matt, Miller Aleisha et autres

Background Accurately assessing the safety of disease-modifying therapies (DMT) is important to ensure that patients and clinicians make fully-informed treatment decisions. Clinical trial data are restricted to narrow populations and may be less applicable to groups such as pregnant women, older people, …

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Multiple sclerosis genetics in an ancestrally-diverse UK population

J Harrison Benjamin, Schalk Luisa, Noyce Alastair, Morris Huw et autres

Background Genome-wide association studies (GWAS) of Multiple Sclerosis (MS) susceptibility and severity have primarily focussed on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to ensure the generalisability of these findings. Methods ADAMS is a nationwide multi-centre …

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多発性硬化症関連ブドウ膜炎の罹患率と人口統計学:英国バイオバンク研究【JST・京大機械翻訳】

Taylor Thomas, Jacobs Benjamin M, Giovannoni Gavin, Petrushkin Harry et autres