Modifiable risk factors for multiple sclerosis are consistent across ethnic backgrounds

Le résumé fourni par la source

Background Epidemiological studies conducted in majority White populations have identified multiple potentially modifiable risk factors for Multiple Sclerosis (MS). It is unknown whether these risk factors differ between ethnic groups. Methods We conducted a nested case-control study using data from the UK Clinical Practice Research Database. MS cases were identified between 1990 and 2022 and controls were matched on year of birth. We used stratified logistic regression models and formal statistical interaction tests to determine whether the effect of modifiable risk factors for MS differed by ethnicity. Results We included 17,400 MS cases (2.6% Asian, 2.4% Black, 93.2% White) and 158,949 age-matched controls. Significant differences in age at first recorded MS diagnosis and the Female:Male ratio between ethnic groups were seen. Established MS risk factors were consistently associated with MS across all ethnic backgrounds, with similar magnitude and direction of effects across ethnic groups examined. Conclusions Established modifiable risk factors for MS are applicable across diverse ethnic backgrounds. Efforts to reduce the population incidence of MS by tackling these risk factors must be inclusive of people from diverse ethnicities.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.